Zinkserumresponse beim Pferd nach oraler Verabreichung von unterschiedlichen Zinkverbindungen

Summary In the here presented study, the zinc serum response was
investigated after the application of 4 different zinc compounds
with varying dosages. To be able to consider species differences,
dogs and cats were also supplemented with the same compounds and
the zinc serum values measured. A total of 4 ponies, 12 dogs and 11
cats were alternately fed with zinc oxide, zinc sulfate, zinc
lactate and B-Traxim using a single dose of 10 mg zinc/kg KM and
the zinc serum levels measured over the next 24 hours. For the
ponies, the effect of a single dose of 20 mg zinc/kg KM (except
zinc lactate) was also measured. In the third approach, the ponies
were supplemented 2,5 mg zinc/kg KM per day for a total of 14 days.
The results were as follows: • The zinc serum level increased
significantly after the application of zinc sulfate and B-traxim in
relation to the dosage (Tab. 1). Zinc lactate also showed signs of
a potential increase but due to the reduced tolerance was only
tested in the lower dosages. In contrast, zinc oxide did not show a
significant zinc serum response regardless of the applied amount.
Tab. 1: Mean values of the maxima with standard deviation (SD) and
minimum / maximum zinc serum values for the ponies (Mean values,
not indicated with the same letter differ significantly) 10 mg Zn /
kg KM 20 mg Zn / kg KM Compound Mean Maxima SD Range Mean Maxima SD
Range Control 860  200b 660-1102 854  209b 649-1146 Zinc oxide
1100  340ab 776-1564 1136  463b 842-1785 Zinc sulfate 2080  800a
1030-2805 4134  1323a 2880-5888 B-Traxim 2120  670a 1397-2885
4895  1497a 3136-6206 Zinc lactate 1810  630ab 1171-2638 • No
significant increase of the zinc serum levels could be found after
the daily application of 2,5 mg zinc/kg KM over the 2 weeks. All
levels were within the range of the ones presented in current
literature. • For the dogs and cats, no significant zinc serum
response could be determined after the supplementation of 10 mg
zinc/kg KM, regardless of the zinc compound. For the cats, it could
be speculated that the zinc serum response showed a certain
tendency to higher serum levels after the application of zinc
sulfate, B-traxim and zinc lactate. For these investigations, it
can be concluded that zinc sulfate and B-traxim are available in
the horse and are thus suited for the use in studies on zinc
supplementation in regards to hoof quality. But one needs to
consider, that from the results presented in this study, it can not
be excluded that zinc oxide or zinc lactate are also available in
the horse under certain circumstances.