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Wissen schafft Macht. Macht aber nix. Oder? WISM²ANO Ein Podcast der BioteXpert*innen Podcast
Inside Piezo4Spine: The Challenge of Spinal Cord Repair

Inside Piezo4Spine: The Challenge of Spinal Cord Repair

Wissen schafft Macht. Macht aber nix. Oder? WISM²ANO Ein Podcast der BioteXpert*innen vor 3 Monaten

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43:03

What if a spinal cord injury never truly ends?

Years after the accident, the body is still under pressure:
chronic inflammation, recurring infections, and neurons that are
alive—but unable to reconnect.

In this episode, we take you inside Piezo4Spine, a European
research project working on a radically different approach to
spinal cord repair.

In this episode

Why “spinal cord injury” is not a single condition

What happens in the body immediately after injury—and years later

Why scar tissue becomes a major barrier to recovery

How the immune system changes long-term

What happens in the brain after losing input

Why previous repair strategies have failed

Piezo4Spine flips the perspective:

Targeting scar-forming cells (fibroblasts) instead of only
neurons

Using nanoparticles for targeted drug delivery

Developing an implantable 3D “theramesh”

Testing everything in preclinical animal models

The idea: before reconnecting nerves, you need to fix the
environment they live in.

Guests:

Dr. Juliana Martins da Rosa

Neurophysiologist focusing on neural circuits and regeneration at
the Hospital for Paraplegics in Toledo (Spain), SESCAM

Dr. Elisa López Dolado

Clinician-scientist specializing in spinal cord injury and
rehabilitation at the Hospital for Paraplegics in Toledo (Spain),
SESCAM

More information: Graphene oxide scaffolds
promote functional improvements mediated by scaffold-invading
axons in thoracic transected rats

Collagen-based scaffolds loaded with iron oxide nanoparticles
promote functional sensorimotor recovery in spinal cord injury |
bioRxivA regenerative rehabilitation strategy based on rGO
scaffolds and treadmill training boosts neural, vascular and
muscle repair features in chronic hemisected rats - ScienceDirect

Follow the Piezo4Spine channels:

LinkedIn

Instagram