TWiV 1239: Aluminum and antibodies

TWiV explains a cohort study of over one million Danish children
which shows no evidence supporting an increased risk for
autoimmune, atopic or allergic, or neurodevelopmental disorders
associated with early childhood exposure to vaccines with
aluminum-base adjuvants, and a study of antibodies induced by
mRNA-1273 and NVX-CoV2373 COVID-19 vaccines which show that
polyclonal antibodies against a single site on the
spike N-terminal domain show immunodominance, high diversity, and
limited cross-reactivity, indicating the need to direct antibody
responses away from this site.


Hosts: Vincent Racaniello, Alan Dove, and Brianne
Barker


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Links for this episode

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No chronic effects of aluminum-based adjuvants in
vaccines (Ann Int Med)

Aluminum in vaccines (CHOP)

Structural serology of antibody responses to COVID
vaccines (Cell Rep)

Letters read on TWiV 1239

Timestamps by Jolene Ramsey. Thanks!

Weekly Picks

Brianne – MHC Class I Antigen
Presentation Video
Alan – We Become What We Behold
Vincent – New Injectable Recommended
by Europe for HIV Prevention


Intro music is by Ronald Jenkees


Send your virology questions and comments to twiv@microbe.tv


Content in this podcast should not be construed as medical
advice.