TWiV 1260: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin with Vincent
Racaniello chat about Jane Goodall’s death and the Nobel prize in
Physiology/Medicine for understanding immune system control
before Dr. Griffin deep dives into recent statistics on the
measles epidemic, RSV, influenza and SARS-CoV-2 infections, the
Wasterwater Scan dashboard, Johns Hopkins measles tracker, if 2
doses of the influenza vaccine are better for protection of first
season children, if COVID-19 negatively impacts pregnancy and the
unborn child, efficacy of long-acting monoclonal antibody against
symptomatic COVID-19, where to find PEMGARDA, how to access and
pay for Paxlovid, can you be retreated with Paxlovid, long COVID
treatment center, where to go for answers to your long COVID
questions, long COVID in pediatrics, association of COVID-19 with
new-onset vascular dementia and contacting your federal
government representative to stop the assault on science and
biomedical research.


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Links for this episode


Jane Goodall’s legacy: three ways she
changed science (Nature)

They understood how the immune system is kept in
check (The Nobel Prize)

Daniel Griffin: The Nobel Prize for
Understanding Autoimmune
Disease (WNYC: New York Public Radio)

Kennedy’s Ties to Ally Leading Vaccine Lawsuits
Raise Ethical Concerns (NY Times)

Ebola outbreak in southern Congo shows signs
of containment with no new cases, WHO
reports (AP News)


Ebola Disease (WHO: African Region)

Premature baby dies from measles
in Alberta as cases throughout province near 2,000(Global News)

DOH Issues Advisory After Measles Detection in City
of Oswego Wastewater (Finger lakes
dailynew.com)


Wastewater for measles (WasterWater Scan)

Measles cases and outbreaks (CDC
Rubeola)

Tracking Measles Cases in the U.S.
(Johns Hopkins)

Measles vaccine recommendations from NYP
(jpg)


Weekly measles and rubella monitoring
(Government of Canada)


Measles (WHO)

Get the FACTS about measles (NY
State Department of Health)


Measles (CDC Measles (Rubeola))


Measles vaccine (CDC Measles (Rubeola))


Presumptive evidence of measles immunity
(CDC)


Contraindications and precautions to
measles vaccination (CDC)


Measles (CDC Measles (Rubeola))

Adverse events associated with childhood
vaccines: evidence bearing on causality (NLM)

Measles Vaccination: Know the
Facts (ISDA: Infectious Diseases Society of America)

Deaths following vaccination: what does
the evidence show (Vaccine)

Influenza: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

Respiratory virus activity levels
(CDC Respiratory Illnesses)

Weekly surveillance report: clift
notes (CDC FluView)

Influenza-Associated Pediatric
Deaths — United States, 2024–25 Influenza Season
(CDC: MMWR)


ACIP Recommendations Summary (CDC:
Influenza)


American Academy of Pediatrics


Flu and Children (CDC: Influenza (flu))

Comparison of 2 Doses vs 1 Dose in
the First Season Children Are Vaccinated Against Influenza (JAMA:
Open Network)

Influenza Vaccine Composition for
the 2025-2026 U.S. Influenza Season
(FDA)

RSV: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

RSV-Network (CDC Respiratory Syncytial virus
Infection)


Vaccines for Adults (CDC: Respiratory
Syncytial Virus Infection (RSV))


Economic Analysis of Protein Subunit and
mRNA RSV vaccination in Adults aged 50-59 Years (CDC: ACIP)

Evidence
to Recommendations Framework
(EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National
Center for Immunization and Respiratory Diseases)


Efficacy and safety of respiratory
syncytial virus vaccines(Cochrane Library)

Waste water scan for 11
pathogens (WastewaterSCan)

COVID-19 deaths (CDC)

Respiratory Illnesses Data
Channel (CDC: Respiratory Illnesses)

COVID-19 national and
regional trends (CDC)

COVID-19 variant tracker (CDC)

SARS-CoV-2 genomes galore
(Nextstrain)

Antigenic and Virological Characteristics of SARS-CoV-2
Variant BA.3.2, XFG, and
NB.1.8.1 (bioRxiV)

Neonatal outcomes among pregnant
women with COVID-19 (BMC
Pregnancy and Childbirth)

Safety and Efficacy of Pemivibart, a
Long-Acting Monoclonal Antibody, for Prevention of Symptomatic
COVID-19 (CID)


Where to get pemgarda (Pemgarda)


EUA for the pre-exposure
prophylaxis of COVID-19 (INVIYD)

Infusion center (Prime Fusions)


CDC Quarantine guidelines (CDC)


NIH COVID-19 treatment guidelines (NIH)

Drug
interaction checker (University of
Liverpool)

Help your eligible patients
access PAXLOVID with the PAXCESS Patient Support
Program (Pfizer Pro)


Understanding Coverage Options
(PAXCESS)


Retreatment With
Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms
and SARS-CoV-2 Positivity (CID)


Infectious Disease Society guidelines for
treatment and management (ID Society)

Molnupiravir safety and efficacy
(JMV)

Convalescent plasma recommendation
for immunocompromised (ID Society)

What to do when sick with a respiratory
virus (CDC)

Managing healthcare
staffing shortages (CDC)


Anticoagulation guidelines
(hematology.org)

Daniel Griffin’s evidence
based medical practices for long COVID (OFID)

Long COVID hotline (Columbia :
Columbia University Irving Medical Center)


The answers: Long COVID

Long COVID associated with SARS-CoV-2
reinfection among children and adolescents in the
omicron era (RECOVER-EHR) (LANCET: Infectious Diseases)

Prevalence and duration of clinical symptoms
of pediatric long COVID (Frontiers in
Pediatrics)

COVID-19 infection associated with increased
risk of new-onset vascular dementia in adults ≥50
years(NPJ| dementia) Reaching out to US house
representative


Letters read on TWiV 1260

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene Ramsey. Thanks!



Intro music is by Ronald Jenkees


Send your questions for Dr. Griffin to daniel@microbe.tv


Content in this podcast should not be construed as medical
advice.