TWiV 1262: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin with Vincent
Racaniello are dismayed by the government shutdown, the firings
at the CDC including EIS agents, H5N1 isolation from backyard
birds and its stability in raw milk and cheese, before Dr.
Griffin deep dives into recent statistics on the measles
epidemic, RSV, influenza and SARS-CoV-2 infections, the
Wasterwater Scan dashboard, Johns Hopkins measles tracker, the
quarantining of college students in the US due to measles,
Japan’s declaration of a national influenza outbreak,
effectiveness of the influenza and COVID vaccines, where to find
PEMGARDA, how to access and pay for Paxlovid, can you be
retreated with Paxlovid, long COVID treatment center, results
from PLATCOV studies- still no antiviral activity attributed to
ivermectin, where to go for answers to your long COVID questions,
long COVID in pediatrics, patient reported outcomes from the
STOP-PASC clinical trial, contacting your federal government
representative to stop the assault on science and biomedical
research and the listener reminder that measles vaccine in those
with interferonopathy may result in severe adverse affects.


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Links for this episode

Trump Administration Lays Off
Dozens of C.D.C. Officials (NY Times)

CDC walks back hundreds of firings
as US shutdown persists (Yahoo News/ Reuters)


CDC battered by government shutdown
firings, while some are rescinded (STAT 10)

Confirmations of Highly Pathogenic Avian Influenza in
Commercial and Backyard
Flocks (USDA: Animal and Plant
Health Inspection Service)

Flurry of H5N1 activity noted in
commercial poultry, wild birds(CIDRAP)

H5N1 influenza virus stability and
transmission risk in raw milk and cheese(Nature
Medicine)

Hundreds of U.S.
students quarantined amid measles outbreaks (NBC
News)


Wastewater for measles (WasterWater Scan)

Measles cases and outbreaks (CDC
Rubeola)

Tracking Measles Cases in the U.S.
(Johns Hopkins)

Measles vaccine recommendations from NYP
(jpg)


Weekly measles and rubella monitoring
(Government of Canada)


Measles (WHO)

Get the FACTS about measles (NY
State Department of Health)


Measles (CDC Measles (Rubeola))


Measles vaccine (CDC Measles (Rubeola))


Presumptive evidence of measles immunity
(CDC)


Contraindications and precautions to
measles vaccination (CDC)


Measles (CDC Measles (Rubeola))

Adverse events associated with childhood
vaccines: evidence bearing on causality (NLM)

Measles Vaccination: Know the
Facts(ISDA: Infectious Diseases Society of America)

Deaths following vaccination: what does
the evidence show (Vaccine)

Influenza: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

Respiratory virus activity levels
(CDC Respiratory Illnesses)

Weekly surveillance report: clift
notes (CDC FluView)


Japan sees early flu activity, with
school closures(CIDRAP)

Japan Declares Nationwide Flu
Outbreak Following Early Surge in Cases
(insightscare)


ACIP Recommendations Summary (CDC:
Influenza)


American Academy of Pediatrics


Flu and Children (CDC: Influenza (flu))


Effectiveness of influenza vaccination to
prevent severe disease (CMI: Clinical Microbiology and
Infection)

Influenza Vaccine Composition for
the 2025-2026 U.S. Influenza
Season(FDA)

RSV: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

RSV-Network (CDC Respiratory Syncytial virus
Infection)


Vaccines for Adults (CDC: Respiratory
Syncytial Virus Infection (RSV))


Economic Analysis of Protein Subunit and
mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)

Evidence
to Recommendations Framework
(EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National
Center for Immunization and Respiratory Diseases)


Efficacy and safety of respiratory
syncytial virus vaccines (Cochrane Library)

Waste water scan for 11
pathogens (WastewaterSCan)

COVID-19 deaths (CDC)

Respiratory Illnesses Data
Channel (CDC: Respiratory Illnesses)

COVID-19 national and
regional trends (CDC)

COVID-19 variant tracker (CDC)

SARS-CoV-2 genomes galore
(Nextstrain)

Antigenic and Virological Characteristics of SARS-CoV-2
Variant BA.3.2, XFG, and
NB.1.8.1 (bioRxiV)

Effectiveness of NVX-CoV2373 and
BNT162b2 COVID-19 Vaccination in South Korean
Adolescents (The Pediatric Infectious Disease Journal)


Trump gets Covid vaccine and flu shot
during second checkup of the year (NBC News)


Where to get pemgarda (Pemgarda)


EUA for the pre-exposure
prophylaxis of COVID-19 (INVIYD)

Infusion center (Prime Fusions)


CDC Quarantine guidelines (CDC)


NIH COVID-19 treatment guidelines (NIH)

Drug
interaction checker (University of
Liverpool)

Help your eligible patients
access PAXLOVID with the PAXCESS Patient Support
Program (Pfizer Pro)


Understanding Coverage Options
(PAXCESS)

Pharmacometrics of high-dose
ivermectin in early COVID-19 from an open label,
randomized, controlled adaptive platform trial (PLATCOV)(eLife)

Antiviral efficacy of oral ensitrelvir versus oral
ritonavir-boosted nirmatrelvir in COVID-19
(PLATCOV) (LANCET: Infectious Diseases)


Infectious Disease Society guidelines for
treatment and management (ID Society)

Molnupiravir safety and efficacy
(JMV)

Convalescent plasma recommendation
for immunocompromised (ID Society)

What to do when sick with a respiratory
virus (CDC)

Managing healthcare
staffing shortages (CDC)


Anticoagulation guidelines
(hematology.org)

Daniel Griffin’s evidence
based medical practices for long COVID (OFID)

Long COVID hotline (Columbia :
Columbia University Irving Medical Center)


The answers: Long COVID

Nirmatrelvir-Ritonavir and Symptoms in Adults
With Postacute Sequelae of SARS-CoV-2
Infection (JAMA Internal Medicine)


Longitudinal patient-reported outcome
trajectories in Long COVID: Findings from the STOP-PASC Clinical
Trial (OFID)

Reaching out to US house representative


Severe Adverse Reaction to Measles
Vaccine Due to Homozygous Mutation in the IFNAR2 Gene: A Case
Report and Literature Review (Journal of Clinical Immunology)


Letters read on TWiV 1262

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene Ramsey. Thanks!



Intro music is by Ronald Jenkees


Send your questions for Dr. Griffin to daniel@microbe.tv


Content in this podcast should not be construed as medical
advice.