TWiV 1266: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin and Vincent Racaniello
ponder the nomination of Casey Means for Surgeon General by
President Trump, how mRNA vaccines may enhance effectiveness of
check point inhibitor cancer therapies, if viral infection
associates with cardiac disease, H5N1 isolation from backyard
birds and turkey farms, and the effectiveness of the COVID-19,
RSV and influenza vaccines before Dr. Griffin deep dives into
recent statistics on the measles epidemic, RSV, influenza and
SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns
Hopkins measles tracker, if revaccination with the mRNA RSV
vaccine is effective, how effective today’s COVID-19 vaccine is
for protection against severe disease following infection with
current viral variants, where to find PEMGARDA, how to access and
pay for Paxlovid, can you be retreated with Paxlovid, long COVID
treatment center, where to go for answers to your long COVID
questions, and contacting your federal government representative
to stop the assault on science and biomedical research.


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Links for this episode

The Challenge of Malignancies in HIV-1, Beyond
Immune Activation and Back to Decreased Immune
Surveillance (Journal of AIDS & Clinical Research)

SARS-CoV-2 mRNA vaccines sensitize
tumours to immune checkpoint blockade (Nature)

TWiV 1265: mRNA vaccines make cancer
treatment great again (microbeTV: TWiV 1265)

Viral Infections and Risk of
Cardiovascular Disease (Journal of the American Heart
Association)

Confirmations of Highly Pathogenic Avian Influenza in
Commercial and Backyard
Flocks (USDA: Animal and Plant
Health Inspection Service)

Three large turkey farms in
Minnesota hit with H5N1 avian flu (CIDRAP)

Updated Evidence for Covid-19, RSV, and
Influenza Vaccines for 2025–2026
(NEJM)


Wastewater for measles (WasterWater Scan)

Measles cases and outbreaks (CDC
Rubeola)

Tracking Measles Cases in the U.S.
(Johns Hopkins)


Weekly measles and rubella monitoring
(Government of Canada)


Measles (WHO)

Get the FACTS about measles (NY
State Department of Health)


Measles (CDC Measles
(Rubeola))


Measles vaccine (CDC Measles (Rubeola))


Presumptive evidence of measles immunity
(CDC)


Contraindications and precautions to
measles vaccination (CDC)

Measles vaccine recommendations from NYP
(jpg)

Adverse events associated with childhood
vaccines: evidence bearing on causality (NLM)

Measles Vaccination: Know the
Facts (ISDA: Infectious Diseases Society of America)

Deaths following vaccination: what does
the evidence show (Vaccine)

Influenza: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

Respiratory virus activity levels
(CDC Respiratory Illnesses)

Weekly surveillance report: Cliff
notes (CDC FluView)


ACIP Recommendations Summary (CDC:
Influenza)

Influenza Vaccine Composition for
the 2025-2026 U.S. Influenza Season
(FDA)

RSV: Waste water scan for 11
pathogens (WastewaterSCan)


Respiratory Diseases (Yale School of
Public Health)

US respiratory virus activity (CDC
Respiratory Illnesses)

RSV-Network (CDC Respiratory Syncytial virus
Infection)


Vaccines for Adults (CDC: Respiratory
Syncytial Virus Infection (RSV))


Economic Analysis of Protein Subunit and
mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)

Safety, Tolerability, and Immunogenicity
of Revaccination With mRNA-1345, an
mRNA Vaccine Against RSV, Administered 12 Months Following a
Primary Dose in Adults Aged ≥50 Years (CID)

Vaccine effectiveness of a
bivalent respiratory syncytial virus (RSV) pre-F vaccine against
RSV-associated hospital admission among adults aged 75–79 years
in England (LANCET: Infectious Diseases)

Waste water scan for 11
pathogens (WastewaterSCan)

COVID-19 deaths (CDC)

Respiratory Illnesses Data
Channel (CDC: Respiratory Illnesses)

COVID-19 national and
regional trends (CDC)

COVID-19 variant tracker (CDC)

SARS-CoV-2 genomes galore
(Nextstrain)

Antigenic and Virological Characteristics of SARS-CoV-2
Variant BA.3.2, XFG, and
NB.1.8.1 (bioRxiV)

Association of 2024–2025 Covid-19 Vaccine with
Covid-19 Outcomes in U.S. Veterans
(NEJM)

Durability of 2024-2025 COVID-19 Vaccines Against
JN.1 Subvariants (JAMA: Internal
Medicine)


Where to get pemgarda (Pemgarda)


EUA for the pre-exposure
prophylaxis of COVID-19 (INVIYD)

Infusion center (Prime Fusions)


CDC Quarantine guidelines (CDC)


NIH COVID-19 treatment guidelines (NIH)

Drug
interaction checker (University of
Liverpool)

Help your eligible patients
access PAXLOVID with the PAXCESS Patient Support
Program (Pfizer Pro)


Understanding Coverage Options
(PAXCESS)


Infectious Disease Society guidelines for
treatment and management (ID Society)

Molnupiravir safety and efficacy
(JMV)

Convalescent plasma recommendation
for immunocompromised (ID Society)

What to do when sick with a respiratory
virus (CDC)

Managing healthcare
staffing shortages (CDC)


Anticoagulation guidelines
(hematology.org)

Daniel Griffin’s evidence
based medical practices for long COVID (OFID)

Long COVID hotline (Columbia :
Columbia University Irving Medical Center)


The answers: Long COVID

Reaching out to US house representative


Letters read on TWiV 1266

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene Ramsey. Thanks!



Intro music is by Ronald Jenkees


Send your questions for Dr. Griffin to daniel@microbe.tv


Content in this podcast should not be construed as medical
advice.