TWiV 1274: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin and Vincent Racaniello
wish everyone a Happy Thanksgiving and then decry appointment of
the Louisiana State surgeon general as deputy chief of the CDC,
the 3 children’s deaths during this fall’s pertussis outbreak,
the Marburg virus outbreak in Ethiopia, results of the phase 1
safety trial for the novel poliovirus vaccines nOPV1 and nOPV3,
and the first human death from H5N5 influenza virus infection in
the US this fall, before Dr. Griffin deep dives into recent
statistics on the measles epidemic, RSV, influenza and SARS-CoV-2
infections, the Wasterwater Scan dashboard, Johns Hopkins measles
tracker, effectiveness of the cell or egg based flu or the mRNA
vaccines, immunogenicity and efficacy of updated COVID-19
vaccines, where to find PEMGARDA, how to access and pay for
Paxlovid, long COVID treatment center, where to go for answers to
your long COVID questions, immune and cognitive dysfunction
during long COVID and contacting your federal government
representative to stop the assault on science and biomedical
research.


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Links for this episode

Anti-science Movement: Deputy
director of CDC (X:Louisiana Office of the Surgeon
General)

CDC’s new deputy director is vocal
critic of vaccines, advocated for ivermectin
(CIDRAP)

Whooping cough cases on the rise in
Texas (FOX4: KDFW)

Third infant in Kentucky dies of whooping
cough as national cases stay high for second year
in a row (CIDRAP)

More than 25,000 whooping cough
cases reported this year as Kentucky records 3rd
infant death (ABC News)

Vaccination Coverage and
Exemptions among Kindergartners (CDC:
SchoolVaxView)

Effects of human papillomavirus
(HPV) vaccination programmes on
community rates of HPV‐related disease and harms from vaccination
(Cochrane Library)

Marburg Outbreak in Ethiopia: Current
Situation (CDC: Marburg Virus Disease)

Safety and immunogenicity of novel live
attenuated type 1 and type 3 oral poliomyelitis
vaccines in healthy adults in the USA: a
first-in-human, observer-masked, multicentre, phase 1 randomised
controlled trial (LANCET: Infectious Diseases)

Washington state resident believed to be the first to die
from a rare strain of bird
flu (AP News)


Wastewater for measles (WasterWater Scan)

Measles cases and outbreaks (CDC
Rubeola)

Tracking Measles Cases in the U.S.
(Johns Hopkins)

Measles vaccine recommendations from NYP
(jpg)


Weekly measles and rubella monitoring
(Government of Canada)


Measles (WHO)

Get the FACTS about measles (NY
State Department of Health)


Measles (CDC Measles
(Rubeola))


Measles vaccine (CDC Measles (Rubeola))


Presumptive evidence of measles immunity
(CDC)


Contraindications and precautions to
measles vaccination (CDC)

Adverse events associated with childhood
vaccines: evidence bearing on causality (NLM)

Measles Vaccination: Know the
Facts (ISDA: Infectious Diseases Society of America)

Deaths following vaccination: what does
the evidence show (Vaccine)

Influenza: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

Respiratory virus activity levels
(CDC Respiratory Illnesses)

Weekly surveillance report: clift
notes (CDC FluView)

Superior Effectiveness and Estimated Public Health Impact
of Cell- Versus Egg-Based Influenza
Vaccines in Children and Adults During the US 2023–2024 Season
(Infectious Diseases and Therapy)

Efficacy, Immunogenicity, and Safety of Modified
mRNA Influenza Vaccine(NEJM)


ACIP Recommendations Summary (CDC:
Influenza)


Types of Influenza Viruses (CDC:
Influenza (flu))

Influenza Vaccine Composition for
the 2025-2026 U.S. Influenza Season
(FDA)

RSV: Waste water scan for 11
pathogens (WastewaterSCan)


Respiratory Diseases (Yale School of
Public Health)

US respiratory virus activity (CDC
Respiratory Illnesses)

RSV-Network (CDC Respiratory Syncytial virus
Infection)


Vaccines for Adults (CDC: Respiratory
Syncytial Virus Infection (RSV))


Economic Analysis of Protein Subunit and
mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)


Estimating Risk of
Guillain-Barré Syndrome in US Medicare-Enrolled Older Adults
Following Medically Attended Respiratory Syncytial Virus Disease
(CID)


FDA Requires Guillain-Barré Syndrome
(GBS) Warning in the Prescribing Information for RSV Vaccines
Abrysvo and Arexvy: FDA Safety Communication (FDA)

Brag Sets Off a Chain Reaction — Dr. Oz Takes the Bait,
But Fumbles the Math, and Starts
Unraveling Mid-Interview (Atlanta BlackStar)

Waste water scan for 11
pathogens (WastewaterSCan)

COVID-19 deaths (CDC)

Respiratory Illnesses Data
Channel (CDC: Respiratory Illnesses)

COVID-19 national and
regional trends (CDC)

COVID-19 variant tracker (CDC)

SARS-CoV-2 genomes galore
(Nextstrain)

Antigenic and Virological Characteristics of SARS-CoV-2
Variant BA.3.2, XFG, and
NB.1.8.1 (bioRxiV)

Effectiveness of the BNT162b2 and mRNA-1273
JN.1-adapted vaccines against COVID-19-associated
hospitalisation and death: a Danish, nationwide, register-based,
cohort study (LANCET: Infectious Diseases)

Immunogenicity of JN.1- and KP.2-Encoding mRNA
COVID-19 Vaccines Against JN.1 Subvariants in Adult
Participants (OFID)

SARS-CoV-2 vaccination
and myositis in Norway and Sweden
(Rheumatology)


Where to get pemgarda (Pemgarda)


EUA for the pre-exposure
prophylaxis of COVID-19 (INVIYD)

Infusion center (Prime Fusions)


CDC Quarantine guidelines (CDC)


NIH COVID-19 treatment guidelines (NIH)

Drug
interaction checker (University of
Liverpool)

Help your eligible patients
access PAXLOVID with the PAXCESS Patient Support
Program (Pfizer Pro)


Understanding Coverage Options
(PAXCESS)


Infectious Disease Society guidelines for
treatment and management (ID Society)

Molnupiravir safety and efficacy
(JMV)

Convalescent plasma recommendation
for immunocompromised (ID Society)

What to do when sick with a respiratory
virus (CDC)

Managing healthcare
staffing shortages (CDC)


Anticoagulation guidelines
(hematology.org)

Daniel Griffin’s evidence
based medical practices for long COVID (OFID)

Long COVID hotline (Columbia :
Columbia University Irving Medical Center)


The answers: Long COVID

Digitally Assessed Long COVID
Symptomatology Is Associated With Lymphocyte
Mitochondrial Dysfunction and Altered Immune Potential (OFID)

Evaluation of Interventions for Cognitive
Symptoms in Long COVID (JAMA Neurology)

Reaching out to US house representative


Letters read on TWiV 1274

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene Ramsey. Thanks!



Intro music is by Ronald Jenkees


Send your questions for Dr. Griffin to daniel@microbe.tv


Content in this podcast should not be construed as medical
advice.