Male vs. Female Brain Differences & How They Arise From Genes & Hormones | Dr. Nirao Shah

My guest is Dr. Nirao Shah, MD, PhD, a professor of psychiatry,
behavioral sciences and neurobiology at Stanford University School
of Medicine. We discuss how the brains of males and females differ
and how those differences arise from different genes and hormones
during fetal development, in childhood and adulthood. We discuss
what drives male- versus female-specific behaviors and how hormonal
fluctuations across the lifespan, including puberty, the menstrual
cycle, menopause and aging – affect behavior, cognition and health.
Additionally, we discuss how biology relates to gender identity and
the impact of hormone therapies on brain circuits that regulate
mating, parenting and social bonding. Read the episode show notes
at hubermanlab.com. Thank you to our sponsors AG1:
https://drinkag1.com/huberman Maui Nui:
https://mauinuivenison.com/huberman Eight Sleep:
https://eightsleep.com/huberman LMNT:
https://drinklmnt.com/huberman Function:
https://functionhealth.com/huberman Timestamps 00:00:00 Nirao Shah
00:02:11 Mice, Humans & Brain, Biological Conservation 00:05:25
Hormones, Nature vs Nurture 00:07:13 Biological Sex Differences,
Chromosomes & SRY Gene, Hormones 00:16:01 Sponsors: Maui Nui
& Eight Sleep 00:19:09 Androgen Mutations, Feminization &
Masculinization 00:22:04 SRY Gene; Animals & Sexual
Trans-Differentiation 00:27:49 Hormones & Biological Brain
Differentiation 00:31:22 Congenital Adrenal Hyperplasia,
Androstenedione; Stress & Pregnancy 00:35:56 Genes, Brain
Differentiation & Sexual Identity; Congenital Adrenal
Hyperplasia 00:43:37 Testosterone, Estrogen & Brain Circuits
00:47:27 Sponsors: AG1 & LMNT 00:50:36 Intersex Individuals,
Castration 00:52:23 Female Sexual Behavior, Brain, Testosterone
& Pheromones 00:57:58 Identify as Heterosexual or Homosexual,
Difference in Hormone Levels? 01:00:42 Gender, Sexual Orientation
& Hormones; Hormone Replacement Therapy 01:10:21 Aromatization;
Steroid Hormones & Gene Expression 01:15:00 Kids & Changing
Gender Identity 01:19:05 Sexual Behavior, Refractory Period &
Male Brain, Tacr1 Cells 01:21:31 Sponsor: Function 01:23:19
Hypothalamus, Dopamine, Prolactin, Cabergoline, Libido, Dopamine
01:27:05 Brain Circuits, Aggression & Sexual Behavior 01:32:40
Refractory Period; Age, Testosterone & Libido 01:36:07 Tacr1
Cells in Females, Periaqueductal Gray & Innate Behaviors
01:40:00 Parenting Behaviors & Brain Circuits; Pet Dogs
01:43:12 Oxytocin, Pair Bonding, Vasopressin; Biological Redundancy
01:47:22 Libido, Melanocortin, Tacr1 Neurons; GLP-1 Agonists,
Clinical Trials; Kisspeptin 01:56:43 Female Brain Changes,
Menstrual Cycle, Pregnancy, Menopause; Estrogen; Men & Hormone
Fluctuation? 02:04:10 Life Experience Male vs Female, Sex
Recognition, Behaviors & Context 02:16:05 Pain Management;
Endocrine Disrupters, Gender Identity 02:21:03 Future Projects
02:24:29 Zero-Cost Support, YouTube, Spotify & Apple Follow
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