Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca

My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and
behavioral sciences at Stanford University. We discuss the biology
and genetics of autism, why autism diagnoses are increasing and
recent progress in using stem cells to understand and treat
profound autism and other brain disorders. Dr. Pașca explains
“organoids and assembloids”—human stem cell–derived tools he
pioneered to study, treat and cure complex brain diseases. We also
discuss ethical and safety issues with using gene editing and stem
cells in humans. Read the episode show notes at hubermanlab.com.
Thank you to our sponsors AG1: https://drinkag1.com/huberman David:
https://davidprotein.com/huberman Helix:
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https://functionhealth.com/huberman Timestamps (00:00) Sergiu Pașca
(02:08) Autism Spectrum Disorder, Incidence, Genetics (07:16) Is
Autism More Common in Males? (09:35) Sponsors: David & Helix
Sleep (11:56) Eye Contact in Babies, Fever; Proposed Causes of
Autism; Genes (18:48) Genetic or Idiopathic Autism Diagnoses,
Timothy Syndrome (21:37) Rise in Autism Diagnoses (26:46) Cause,
Correlation & Neurological Disease; Schizophrenia, Do Vaccines
Cause Autism? (31:34) Global Increase in Autism; Gene Therapy,
CRISPR, Follistatin (41:05) Sponsors: AG1 & BetterHelp (43:41)
Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models
(52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers,
Autistic Kids (59:30) Organoids, Modeling Brain Development,
Intrinsic Development Timer (1:12:22) Assembloids, Brain Cell
Migration & Circuit Formation, Self-Organization (1:21:22)
Four-Part Assembloid, Sensory Assembloid, Pain Conditions (1:25:45)
Sponsor: Function (1:27:33) Future Medical Therapies, Cell Banking,
Immortalize Tissues, Rejuvenate Cells (1:34:56) Assembloids &
Ethics, Importance of Nomenclature, Science Collaboration &
Self-Correction (1:45:38) Cell Transplantation & Ethics, Timing
(1:55:05) Genetic Testing for Parents, Genetic Penetrance (2:02:36)
Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia
(2:14:30) Scientific Career, Walking, Art, Medical School (2:20:44)
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