Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In this Huberman Lab Essentials episode, my guest is Dr. David
Sinclair, PhD, a professor of genetics at Harvard Medical School
and a leading expert on the biology of aging. We discuss the
cellular and molecular mechanisms of aging—and how specific
behaviors, such as fasting, regular exercise and NAD⁺-boosting
compounds like NMN, can activate the body's natural longevity
pathways. This discussion highlights how lifestyle choices
profoundly influence the aging process and may even slow or reverse
key aspects of biological aging. Read the episode show notes at
hubermanlab.com. Thank you to our sponsors AGZ by AG1:
https://drinkagz.com/huberman David:
https://davidprotein.com/huberman Eight Sleep:
https://eightsleep.com/huberman Timestamps (0:00) David Sinclair
(0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of
Aging; Epigenome & Genes (4:53) CD & Scratches Analogy,
DNA, Silencing & Expressing Genes (6:44) Physical Appearance
& Aging (7:36) Sponsor: David (8:54) Childhood Development
& Aging, Horvath Clock, Accelerate Aging (11:30) Rates of
Puberty & Aging, Growth Hormone (12:37) Body Size &
Longevity; Epigenetics (13:07) Fasting, Calorie Restriction &
Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a
Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07)
Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16)
Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing
Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions
(27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight
Sleep (31:10) Iron & Senescent Cells; Personalize Medicine
(32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic &
Resistance Exercise (35:55) Estrogen, Fasting & Fertility;
Aging & Rejuvenation (38:20) Acknowledgements Disclaimer &
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