Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum

My guest is Dr. David Fajgenbaum, MD, professor of translational
medicine and human genetics at the University of Pennsylvania. He
explains how, unbeknownst to most doctors, many approved
medications can successfully treat or even cure diseases other than
the ones they are typically used to treat. He shares his story of
escaping death from Castleman's disease by discovering a
life-saving treatment using repurposed drugs that were approved for
other purposes. Our conversation explores how researchers,
physicians, and you—the general public—can explore novel treatments
and cures to conditions the medical profession has deemed
untreatable, including cancers. We also discuss the crucial role of
mindset in battling diseases and the lesser-known use of compounds
to promote health and longevity. Read the episode show notes at
hubermanlab.com. Thank you to our sponsors AGZ by AG1:
https://drinkagz.com/huberman Eight Sleep:
https://eightsleep.com/huberman Rorra: https://rorra.com/huberman
David: https://davidprotein.com/huberman Function:
https://functionhealth.com/huberman Timestamps (0:00) David
Fajgenbaum (4:06) Self-Agency in Healthcare; New Uses for Old
Medicines (6:44) Other Uses of Aspirin & Viagra; Drug
Development & Approved Use (8:53) Lidocaine & Breast
Cancer; Pharmaceutical Companies & Incentives (11:36) Sponsors:
Eight Sleep & Rorra (14:16) Pharmaceutical Companies, Patents
& New Uses; Lithium (18:40) Tools: Finding Reliable Health
Sources, Asking Questions & Disease Organizations; DADA2
Treatment (21:53) Medical Community & Connections; Integrated
Medical Databases (24:36) Drug Repurposing, Thalidomide,
Pembrolizumab (28:45) Medical Research Databases, Mapping Disease
Connections (33:51) Every Cure Database & Programs,
Bachmann-Bupp Syndrome; Colchicine & Heart Disease (37:57)
Sponsors: AGZ by AG1 & David (40:41) David’s Medical &
Career Journey, Glioblastoma, Castleman Disease (49:10) Autoimmune
Disease, Driven Personality, Stress & Immune System (52:52)
Castleman Disease, Treatment, Chemotherapy (55:54) Physician
Continuing Education, Santa Claus Theory of Civilization; Science
Collaboration (1:03:32) Medical School, Relapse & “Overtime”,
Finding a New Treatment, Rapamycin (1:12:46) Sport, Football &
Resilience; Challenge & Personal Growth, Family (1:18:41)
Sponsor: Function (1:20:29) Social Support; “Overtime”, Gratitude
(1:23:19) Business School, Castleman Disease Treatment; Repurposing
Drugs & AI (1:28:29) Drug Repurposing, POEMS Syndrome;
Mitigating Risk (1:35:32) Nicotine, Compounds for Preventive
Health; GLP-1 Agonists (1:40:51) Bioprospecting, Drug Development;
AI, Prioritization & Novel Connections (1:46:18) Healthcare
& Children; Hope, Action & Impact Circuit; Challenge &
Super-Agers (1:52:50) Get Involved with Every Cure (1:56:20)
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