TWiV 1222: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin with Vincent
Racaniello discusses vaccination trends, the changes COVID-19
vaccine recommendations for children and pregnant women, easing
of vaccination exemptions in Texas, the ongoing measles outbreak
globally before Dr. Griffin reviews recent statistics on RSV,
influenza and SARS-CoV-2 infections the Wasterwater Scan
dashboard, whether or not the NB.1.8.1 should be included in the
fall 2025 vaccines and concern as confirmed diagnosis of COVID-19
rise here and in China, different mechanisms by which to reduce
transmission of respiratory pathogens, the May 22 VRBPAC COVID-19
vaccine meeting, where to find PEMGARDA, prolonged steroid and
antibiotic therapies, provides information for Columbia
University Irving Medical Center’s long COVID treatment center,
where to go for answers to your long COVID questions, how spike
protein may alter mast cells and the immune response and
contacting your federal government representative to stop the
assault on science and biomedical research.


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Links for this episode

Vaccination trends (CDC:
Respiratory Illnesses)

Weekly COVID-19 Vaccination
Dashboard (CDC: COVIDVaxView)

RFK Jr ends coronavirus shot
recommendation for healthy children and pregnant women
(Washington Post)

Characteristics of Children Ages 1–17 Who Died
of COVID-19 in 2020–2022 in the United States
(American Academy of Pediatrics)

RFK Jr.’s War on
Children (Paul Offit: Beyond the
Noise)

AAP analyzes pediatric COVID-19
hospitalizations from 2020-’24 (American Academy of Pediatrics)

COVID-19–Associated Hospitalizations
among Children and Adults — COVID-NET
(CDC: National Center for Immunizations and Respiratory Diseases)

COVID-19–Associated Hospitalizations
among Children and Adults — COVID-NET
(CDC: National Center for Immunizations and Respiratory Diseases)

Long COVID in Children (CDC: NCHS)

Long
COVID Prevalence and
Associated Activity Limitation in US Children (JAMA Pediatrics)

The C.D.C. Now Says Healthy Kids Don’t Need Covid
Shots. Is That True? (NY Times)

U.S. Will No Longer
Recommend Covid Shots for Children and Pregnant
Women (NY TImes)


Gregg Abbott (AP News)

US school-entry vaccination rates
fall as exemptions keep rising (AP News)

Whooping cough cases are rising
again in the US (AP News)

Amid measles outbreak, Texas is poised to
make vaccine exemptions for kids
easier (AP News)


Cardiac Events in Adults Hospitalized for
Respiratory Syncytial Virus vs COVID-19 or Influenza (JAMA
Network Open)

USDA reported H5N1 bird flu detection in wild
birds (CDC: Avian Influenza)

USDA reported H5N1 in
poultry (CDC: Avian Influenza)

HPAI Confirmed Cases in Livestock
(USDA Animal and Plant Health Inspections Service)


H5 bird flu: current situation (CDC: Avian
Influenza)


Bird flu (CDC: Avian Influenza)

Measles cases and outbreaks (CDC
Rubeola)


Weekly measles and rubella monitoring
(Government of Canada)


Measles (WHO)

Measles vaccine recommendations from NYP
(jpg)

Get the FACTS about measles (NY
State Department of Health)


Measles (CDC Measles (Rubeola))


Measles vaccine (CDC Measles (Rubeola))


Presumptive evidence of measles immunity
(CDC)


Contraindications and precautions to
measles vaccination (CDC)


Measles (CDC Measles (Rubeola)

Adverse events associated with childhood
vaccines: evidence bearing on causality (NLM)

Measles Vaccination: Know the
Facts(ISDA: Infectious Diseases Society of America)

Deaths following vaccination: what does
the evidence show (Vaccine)

Influenza: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

Weekly surveillance report: clift
notes (CDC FluView)

Respiratory virus activity levels
(CDC Respiratory Illnesses)

Weekly surveillance report: clift
notes (CDC FluView)


FDA-CDC-DOD: 2025-2046 influenza vaccine
composition (FDA)

RSV: Waste water scan for 11
pathogens (WastewaterSCan)

US respiratory virus activity (CDC
Respiratory Illnesses)

RSV-Network (CDC Respiratory Syncytial virus
Infection)

Respiratory syncytial virus:
an under-recognized healthcare-associated
infection (Infection Control & Hospital Epidemiology)

Waste water scan for 11
pathogens (WastewaterSCan)

COVID-19 deaths (CDC)

COVID-19 national and
regional trends (CDC)

COVID-19 variant tracker (CDC)

SARS-CoV-2 genomes galore
(Nextstrain)

Antigenic and Virological Characteristics of SARS-CoV-2
Variant BA.3.2, XFG, and
NB.1.8.1 (biRxiV)

New Covid variant NB.1.8.1 detected at US airports amid rise
in cases

U.S. reports cases of new COVID variant NB.1.8.1
behind surge in
China (CBS News)

WHO TAG-VE Risk Evaluation for
SARS-CoV-2 Variant Under Monitoring: NB.1.8.1 (WHO)

New COVID variant
NB.1.8.1 detected at US airports amid rise in cases
(The Economic Times: News)


Infection Control Guidance: SARS-CoV-2 (CDC:
COVID-19)

Isolating the burden of transmission-based
precautions for COVID-19 (Infection Control &
Hospital Epidemiology)

A pilot study of coughing into the shirt
to disrupt respiratory
pathogen transmission (International Journal of Emergency
Medicine)

Hybrid B- and T-Cell Immunity Associates
With Protection Against
Breakthrough Infection After Severe Acute Respiratory Syndrome
Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents
and Children (ALSPAC) Participants (JID)

FDA panel is split on updates to COVID shots
as questions loom for fall
vaccinations(AP News)

COVID-19 Vaccines (2025-2026 Formula)
for Use in the United States Beginning in Fall 2025(FDA)

Interim Clinical
Considerations for Use of COVID-19 Vaccines in the
United States (CDC: COVID-19)


Where to get pemgarda (Pemgarda)


EUA for the pre-exposure
prophylaxis of COVID-19 (INVIYD)

Infusion center (Prime Fusions)


CDC Quarantine guidelines (CDC)


NIH COVID-19 treatment guidelines (NIH)

Clinical effectiveness of oral antiviral treatment for
non-hospitalized high-risk patients with COVID-19
during Omicron JN.1
subvariant wave(Pneumonia)

Drug
interaction checker (University of
Liverpool)


Infectious Disease Society guidelines for
treatment and management (ID Society)

A Systematic Review and Meta-analysis of
the Effectiveness of Remdesivir to
Treat Severe Acute Respiratory Syndrome Coronavirus 2 in
Hospitalized Patients (CID)

Molnupiravir safety and efficacy
(JMV)

Convalescent plasma recommendation
for immunocompromised (ID Society)

What to do when sick with a respiratory
virus (CDC)

Managing healthcare
staffing shortages (CDC)

Steroids,dexamethasone at the right
time (OFID)


Anticoagulation guidelines
(hematology.org)

Tocilizumab, sarilumab and anakinra
in critically ill patients with
COVID-19 (Thorax)

Daniel Griffin’s evidence
based medical practices for long COVID (OFID)

Long COVID hotline (Columbia :
Columbia University Irving Medical Center)


The answers: Long COVID

Spike proteins of coronaviruses activate mast cells
for degranulation via stimulating
Src/PI3K/AKT/Ca2+ intracellular signaling cascade (Journal
of Virology)

Reaching out to US house representative


Letters read on TWiV 1222

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene Ramsey. Thanks!



Intro music is by Ronald Jenkees


Send your questions for Dr. Griffin to daniel@microbe.tv


Content in this podcast should not be construed as medical
advice.