Supplements for Longevity & Their Efficacy | Dr. Peter Attia

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and
Johns Hopkins School of Medicine-trained physician expert in
improving human healthspan and lifespan. Dr. Attia is also the host
of The Drive podcast and author of the best-selling book
Outlive.  We discuss the NAD pathway in human cells and its
possible links to aging and health. We evaluate how supplementation
can augment molecules in the NAD pathway; we compare NAD, NMN, and
NR, different routes of administration, their safety, and
bioavailability. Then, we discuss the broader research and clinical
literature on longevity to decide if supplementation with NAD, NR,
NMN, rapamycin, or resveratrol can indeed extend lifespan. 
Finally, we each describe our supplement regimens and compare the
role of supplementation to behaviors such as sleep, nutrition, and
exercise for longevity. We also discuss whether tests of biological
age are true indicators of aging and whether normal radiation
levels increase cancer risk.  Listeners of this episode will
learn if supplements purported to improve lifespan show any
efficacy and the behaviors and other factors that can prevent
disease and extend lifespan. Access the full show notes for this
episode at hubermanlab.com. Thank you to our sponsors AG1:
https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman
Levels: https://levels.link/huberman Eight Sleep:
https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter
Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight
Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter’s
Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway:
Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35
Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction &
Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan
00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform
with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive
Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs
NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN,
Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty
Liver Disease & NR; NMN & Glucose; Clinical Significance
01:25:17 Safety & FDA, NMN & NR Supplementation; Skin
Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation,
Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37
Biological Aging Tests, Chronologic & Biologic Age; Vigor 
01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in
50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing
& Energy Levels 02:11:22 Peter’s Supplements 02:18:46 Andrew’s
Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors;
Titanic Analogy  02:26:52 NAD Pathway Supplementation for
Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple
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