Inflam-Aging: Matt Yousefzadeh, PhD

What is senescence? What about autophagy? What role does caloric
restriction play in senescent cells? How does rapamycin impact
vaccine efficacy? What do we need to know about fisetin and
quercetin? What is the #1 thing that we should avoid to protect
our DNA? 


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Matt Yousefzadeh, PhD is an instructor and researcher at Columbia
University and specializes in aging, cancer, DNA repair,
immunology, senescence, and more. He joins us to discuss
inflammaging, senescence, the impact of rapamycin on vaccine
efficacy, the #1 thing we should avoid to protect our DNA, and
more. 


“We’re losing our ability to respond to new challenges as we
progress through time.” 


“When they gave the elderly a version of rapamycin and then gave
them an annual influenza vaccination, they made 20% more
antibodies against influenza, and the immune cells or T cells
showed reduced markers of exhaustion.” 


“If you take old mice, the equivalent of an elderly individual,
and then put them on fisetin, just supplemented in the chow, it
made them live a little bit longer but it also reduced their
senescent cell burden and many markers of pathology in their
tissues, or improved some of their physiological function.” 


“As our bodies age, all our tissues are aging at different times
and different rates.”


“By and large, the things that we can affect in our everyday life
are things like diet and exercise. We also know, too, that
chronic stress has been shown to shorten life, social stress has
been shown to shorten the lifespan of mice. We even see that
social stress can have an impact on our immune function.” 


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Connect with Matt & resources mentioned:
Matt's LinkedIn
American Aging Association
The Gerontological Society of America 


Say hi to the AGEIST team!