How Hormones Shape Sexual Development

In this episode, I discuss how hormones such as testosterone and
estrogen and their derivatives impact the early development of the
brain and body and their maturation. I review published data on
environmental factors shown to powerfully alter hormone pathways in
animals and humans and the effects of cannabis, alcohol and cell
phones on testes, sperm, ovaries and hormones. I describe the
predictable relationship between genes, beard growth and balding
patterns, and the importance of estrogen for brain development in
people of all chromosomal sexes. Finally, I discuss how the
hormones we are exposed to in the womb shape the relative length of
our finger digits, the sounds our ears make (yes you read that
correctly), and how those correlate with people's self-reports of
their sexual preferences. As always, basic information and tools
are discussed. Read the full show notes for this episode at
hubermanlab.com. Thank you to our sponsors AG1:
https://athleticgreens.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Waking Up:
https://www.wakingup.com/huberman Timestamps 00:00:00
Introduction   00:00:30 AG1, LMNT & Waking
Up   00:06:47 Announcement: Mood Meter App Works
Again   00:08:00 Maximizing Learning from the
Podcast   00:10:00 New Non-Sleep Deep Rest Protocol,
Spanish Subtitles   00:11:35 Sexual Differentiation:
Hormones, Neurons & Behavior   00:14:15 Hormones
Basics   00:15:26 Sperm Meets Egg, Chromosomal Sex,
Gonadal Sex   00:17:50 Y Chromosome Inhibition of
Feminization   00:19:00 Placenta Is An Endocrine
(Hormone-Producing) Organ, Adrenal Testosterone  
00:19:45 Hormonal Sex, Morphological Sex   00:21:04
Hormones Fast & Slow, Sex Steroids Can Turn On
Genes   00:23:06 Masculinization, Feminization,
Demasculinization, Defeminization   00:23:42 Primary
Sexual Characteristics: DHT Drives Penis Development  
00:27:03 Secondary Sexual Characteristics   00:27:43
Penis Sprouting: Guevedoces   00:31:25 Estrogen, NOT
Testosterone, Masculinizes The Brain   00:33:15 Breast
Development In Males: Aromatase; Puberty, & Steroids in
Athletes   00:34:50 Estrogen Powerfully Controls Brain
Development In All Individuals   00:35:19 Avoiding
Hormonal Disruption In Children & Adults: Specific Oils,
Creams, Etc.   00:39:00 Environmental Endocrine
Disruptors, Sperm Count Decline, Vincloziline   00:44:20
Androgen Insensitivity Syndrome: Hormones Need Receptors,
SARMS   00:48:41 Estrogen Establishes “Masculine” Brain
Circuits, Testosterone   00:49:42 Cannabis, Alcohol: In
Babies, Puberty & Adults   00:56:25 Cell Phone
Technology: Effects On Hormones, Ovaries, &
Testicles   01:02:33 Beards & Baldness Patterns
Around the World, DHT, 5-alpha-reductase   01:06:39
Creatine & DHT/Hair Loss   01:08:20 Predicting Aging
Rates By Pubertal Rates   01:10:04 Hyenas, Baseball,
& Jumbo Clitorises: Androstenedione   01:14:26
Intersex Moles   01:15:40 Marijuana Plants, Pollens:
Plant-To-Animal “Warfare”   01:20:08 Finger Length
Ratios, Prenatal Hormone Exposure & Sexual
Orientation   01:29:13 Brain Dimorphisms with Sexual
Orientation   01:32:00 “Older Brother Effects”: Male
Fetuses Might Change Mothers & Subsequent Brothers  
01:35:06 The Path Forward & A Warning   01:35:55
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