The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In this episode, I am joined by Dr. David Sinclair, tenured
Professor of Genetics at Harvard Medical School and an expert
researcher in the field of longevity. Dr. Sinclair is also the
author of the book Lifespan: Why We Age & Why We Don't Have To,
and the host of the Lifespan Podcast, which launches January 5,
2022.  In this interview, we discuss the cellular and
molecular mechanisms of aging and what we all can do to slow or
reverse the aging process. We discuss fasting and supplementation
with resveratrol, NAD, metformin, and NMN. We also discuss the use
of caffeine, exercise, cold exposure, and why excessive iron load
is bad for us. We discuss food choices for offsetting aging and
promoting autophagy (clearance of dead cells). And we discuss the
key blood markers everyone should monitor to determine your
biological versus chronological age. We also discuss the future of
longevity research and technology. This episode includes lots of
basic science and specific, actionable protocols, right down to the
details of what to do and when. By the end, you will have in-depth
knowledge of the biology of aging and how to offset it. Read the
full show notes for this episode at hubermanlab.com. Thank you to
our sponsors AG1: https://athleticgreens.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Waking Up:
https://wakingup.com/huberman Momentous:
https://livemomentous.com/huberman Timestamps 00:00:00 Dr. David
Sinclair, Harvard Medical School   00:03:45 Sponsors:
AG1, LMNT & Waking Up 00:07:45 “Aging as a Disease” vs.
Longevity & Anti-Aging   00:10:23 What Causes Aging?
The Epigenome   00:15:53 Cosmetic Aging  
00:17:15 Development Never Stops, Horvath Clock  
00:20:12 Puberty Rate as a Determinant of Aging Rate  
00:23:00 Fasting, Hunger & Food Choices   00:32:44
Fasting Schedules, Long Fasts, (Macro)Autophagy  
00:34:50 Caffeine, Electrolytes   00:35:56 Blood Glucose
& the Sirtuins; mTOR   00:37:55 Amino Acids: Leucine,
“Pulsing”   00:44:35 Metformin, Berberine  
00:50:29 Resveratrol, Wine   00:53:20 What Breaks a
Fast?   00:56:45 Resveratrol, NAD, NMN, NR; Dosage,
Timing   01:09:10 Are Artificial Sweeteners Bad for
Us?   01:12:04 Iron Load & Aging   01:15:05
Blood Work Analysis   01:19:37 C-Reactive Protein,
Cholesterol: Serum & Dietary   01:26:02 Amino Acids,
Plants, Antioxidants   01:33:45 Behaviors That Extend
Lifespan, Testosterone, Estrogen   01:40:35
Neuroplasticity & Neural Repair   01:46:19 Ice Baths,
Cold Showers, “Metabolic Winter”   01:48:07 Obesity &
How It Accelerates Aging, GnRH   01:52:10 Methylation,
Methylene Blue, Cigarettes   01:56:17 X-Rays  
01:59:00 Public Science Education, Personal Health  
02:05:40 The Sinclair Test You Can Take:
www.doctorsinclair.com   02:08:13 Zero-Cost Support &
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