Biology & Treatments for Compulsive Behaviors & Binge Eating | Dr. Casey Halpern

My guest is Casey Halpern, M.D., Chief of Stereotactic and
Functional Neurosurgery and Professor of Neurosurgery at the
Perelman School of Medicine at the University of Pennsylvania. Dr.
Halpern’s research and clinical practice focus on using deep brain
stimulation to treat compulsive and movement disorders (e.g., binge
eating disorders, bulimia, obsessive-compulsive disorder (OCD) and
Parkinson’s disease essential tremor, dystonia). We discuss using
deep brain stimulation to help patients who suffer from movement
and compulsive disorders and applying this treatment to patients
afflicted with binge eating. We also explore applications of this
technology to other conditions such as OCD, anorexia and tremor,
and the future therapeutic directions of the use of non-invasive
brain stimulation approaches, including transcranial magnetic
stimulation and ultrasound, for the treatment of other psychiatric
illnesses and conditions. This episode will interest those curious
about the biology of eating, anorexia, bulimia, compulsive thoughts
and behaviors, and movement. For the full show notes, visit
hubermanlab.com. Thank you to our sponsors AG1:
https://athleticgreens.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Waking Up:
https://wakingup.com/huberman Momentous:
https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Casey
Halpern & Disordered Eating & Brain Stimulation (00:03:35)
Sponsor: LMNT (00:08:28) Neurosurgeon’s View of the Brain,
Neurosurgery Specialization (00:13:05) Deep Brain Stimulation &
Other Unexpected Positive Effects (00:17:20) Obsessive Compulsive
Disorder (OCD), Prescriptions & Cognitive Therapies (00:25:40)
Brain Areas in OCD, Risk, Rewards & Addiction (00:29:30)
Sponsor: AG1 (00:32:27) Facial and Vocal Ticks, Stimulants, Stress
& Superstition (00:39:28) Nucleus Accumbens, Reward Circuits,
Eating Disorders & Obesity (00:47:18) Stimulation of Nucleus
Accumbens, Continuous vs. Episodic Stimulation (00:49:49) Binge
Eating Disorder & Loss of Control Eating (00:53:02) Developing
Binge Eating Disorder: Predisposition, Environment, Stress
(01:02:07) Electrodes in Nucleus Accumbens, Identifying “Craving
Cells” (01:11:41) Effects of Stimulation, Interrupting Craving,
Intermediate Stimulation (01:16:46) Anorexia, Obesity &
Compulsions, Potential Treatments for Anorexia (01:23:14)
Non-Invasive Brain Stimulation, Transcranial Magnetic Stimulation
(01:32:27) MRI-Guided Focused Ultrasound: Tremor, Essential Tremor
& Parkinson’s (01:36:40) Future of Non-Invasive Brain
Stimulation, Epilepsy & Depression (01:41:51) Pre-Behavioral
States in Compulsion & Awareness, Mood Provocation (01:48:02)
Machine Learning/Artificial Intelligence & Compulsion
Predictions (01:53:05) Neurosurgeon Hands, Resistance Training
& Deadlifts (01:59:00) “Neurosurgeon Calm,” Quality Time &
Prioritization, Neurosurgeon Training (02:09:53) Daily Habits:
Sleep, Exercise, Mediation (02:11:59) Zero-Cost Support,
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