Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams

In this episode, my guest is Nolan Williams, M.D., a triple
board-certified psychiatrist, neurologist and professor of
psychiatry and behavioral sciences at Stanford School of Medicine.
He is also the Director of the Stanford Brain Stimulation Lab. We
discuss clinical applications for brain stimulation, behavioral
protocols and novel drug treatments to halt and reverse mental
health disorders, including depression and post-traumatic stress
disorder (PTSD). We first discuss the neural circuits for
self-identity and mood and stress control. We discuss Dr. Williams’
work using transcranial magnetic stimulation (TMS) to depression,
trauma, PTSD, and other mood disorders. We then dive deep into the
history, biology, modern use, and safety margins of the various
psychedelics, including MDMA, LSD, ketamine, ibogaine, ayahuasca,
and psilocybin, as well as cannabis and the use of SSRIs in both
adults and children. Finally, we discuss behavioral treatments for
mental health disorders, including sleep and sleep deprivation,
light exposure, exercise, and training to control the
brain-heart-rate pathways. Regardless of age, all those interested
in mental health should benefit from the incredible breadth and
depth of Dr. Williams’ knowledge and the clarity with which he
conveys that information. For the full show notes, visit
hubermanlab.com. Thank you to our sponsors AG1:
https://athleticgreens.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Waking Up:
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https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Nolan
Williams, Brain Stimulation & Depression Treatment (00:03:48)
Sponsors: LMNT (00:09:16) Depression, Risk Factors, Emergency
Psychiatric Treatments (00:15:11) The Brain-Heart Connection, Vagus
Nerve, Prefrontal Cortex (00:17:51) Right vs. Left Brain
Hemispheres & Mood Balance, Connectome (00:22:34) Heart Rate
& Depression, Behavioral Interventions, Transcranial Magnetic
Stimulation (TMS) (00:33:02) Prefrontal Cortex & Cognitive
Control, TMS (00:35:30) Sponsor: AG1 (00:39:00) Belief/Identity
“Rules”, Re-scripting, TMS & Talk Therapy (00:45:49)
Dorsolateral Prefrontal Cortex, TMS & Depression Treatment
(00:48:36) Cingulate Cortex & Emotion, Dissociation &
Catatonia (00:54:27) Ketamine, the Opioid System & Depression;
Psychedelic Experience or Biology? (01:03:42) SSRIs, Serotonin
& Depression; Childhood, Chemical Imbalance or Circuit?
(01:13:58) Memories & “Rule” Creation; Psilocybin & “Rule”
Resolution (01:21:00) MDMA & Post-Traumatic Stress Disorder
(PTSD) Treatment, Psilocybin & Depression Treatment (01:24:12)
Is MDMA Neurotoxic?, Drug Purity, Dopamine Surges, Post-MDMA
Prolactin (01:30:38) Psilocybin, Brain Connectivity &
Depression Treatment (01:34:53) Exposure Response Prevention:
“Letting Go” & Depression Treatment (01:41:23) Normal Spectrums
for Mental Health Disorders (01:45:35) Ibogaine & “Life
Review”; PTSD, Depression & Clinical Trials (01:57:16) Clinical
Use of Psychedelics (02:01:59) Ayahuasca, Brazilian Prisoner Study
(02:06:55) Cannabis: THC, CBD & Psychosis, Clinical Uses
(02:14:52) Personal Relative Drug Risk & Alcohol (02:20:42)
Circadian Reset for Depression, Sleep Deprivation, Light (02:28:43)
Stanford Neuromodulation Therapy (SNT) Study (02:34:25) Space
Learning Theory & TMS Stimulation (02:45:35) Zero-Cost Support,
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