Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

In this episode, I explain how medications such as Adderall,
Ritalin, Vyvanse and other stimulants work to increase focus and
treat attention-deficit/hyperactivity disorder (ADHD). I explain
the brain circuits involved in focus and the key roles dopamine and
norepinephrine play in their regulation. Then I explain how
stimulants such as Adderall and Vyvanse can increase focus and
reduce hyperactivity in kids or adults with ADHD, and how and why
Ritalin and other medications (e.g., Modafinil, Guanfacine) may
work better for some. I explain the long-term effects of ADHD
medications on height, cardiovascular health, hormones,
predisposition to addiction and psychosis, and whether these
treatments can be used and then stopped. I also discuss the immense
individual variation in dosage sensitivity for these medications
and the negative side-effects that occur from recreational use.
This episode ought to benefit anyone with ADHD, their parents,
those on ADHD medications or anyone curious about how these
medications work. For the full show notes, visit hubermanlab.com.
Thank you to our sponsors AG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab Waking Up:
https://wakingup.com/huberman Momentous:
https://livemomentous.com/huberman Timestamps (00:00:00) Stimulants
& Attention-Deficient/Hyperactivity Disorder (ADHD) (00:03:38)
Sponsors: LMNT & Waking Up (00:06:35) The Brain-Body Contract
(00:07:22) Attention, Prefrontal Cortex & ADHD (00:16:27)
Stimulants “Sympathomimetics” (00:21:29) Adderall, Dopamine &
Norepinephrine (00:25:58) Sympathomimetics, Dopamine &
Norepinephrine (00:27:21) Sponsor: AG1 (00:32:20) Vyvanse is
Timed-Release D-Amp (00:36:36) Ritalin, Concerta (00:40:10)
Dopamine & “Noise Reduction”; Norepinephrine & “Signal
Amplification” (00:45:28) ADHD: Focus, Hyperactivity &
Impulsivity; Drug Selection & Dose (00:50:57) How do Stimulants
‘Calm’ ADHD? (00:54:480 Neuroplasticity & Neuromodulators
(00:58:06) Kids, ADHD Diagnosis & Treatment; Predispose
Addiction? (01:05:12) ADHD Medications: Individuality, Doses,
Tapering & Long-Term Use (01:13:28) Medication & Long-Term
Effects: Height, Cardiovascular Risk, Alcohol (01:19:32) Cortisol
& Hormones (01:27:45) Psychosis & Addiction;
Methamphetamine (01:38:20) Recreational Use, Addiction &
Psychosis; Habituation (01:42:30) Drug Holidays; Ritalin &
Long-Term Effects (01:45:35) Modafinil, Armodafinil; Side-Effects
(01:53:03) Guanfacine, Alcohol (01:58:03) ADHD Medications
(02:00:26) Zero-Cost Support, YouTube Feedback, Spotify & Apple
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