Journal Club With Dr. Peter Attia | Metformin for Longevity & the Power of Belief Effects

In this journal club episode, my guest is Stanford and Johns
Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the
host of The Drive podcast and the author of the bestselling book
"Outlive: The Science & Art of Longevity." We each present a
scientific paper and discuss the findings' strengths, weaknesses
and actionable takeaways. First, we discuss an article that
addresses whether taking the drug metformin can enhance longevity.
Then, we discuss an article on belief effects (similar to placebo
effects), showing how the effects of a drug on the brain and
cognition depend on one's belief about the dose of the drug taken,
not the actual dose. Our conversation also highlights how to read,
interpret and critique scientific studies. This episode ought to be
of interest to those curious about health and longevity, medicine
and psychology and for anyone seeking to better understand how to
read and digest scientific findings. For show notes, including
referenced articles and additional resources, please visit
hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform,
for a summary, clips, and insights from this episode. Thank you to
our sponsors AG1: https://drinkag1.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Waking Up:
https://wakingup.com/huberman Momentous:
https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Peter
Attia, Journal Club (00:03:43) Sponsors: LMNT & Waking Up
(00:06:11) Dreams (00:12:36) Article #1, Metformin, Mitochondria,
Blood Glucose (00:19:47) Type 2 Diabetes & Causes, Insulin
Resistance (00:25:30) Type 2 Diabetes Medications, Metformin,
Geroprotection, Bannister Study (00:36:37) Sponsor: AG1 (00:37:15)
TAME Trial; Demographics, Twin Cohort (00:44:27) Metformin &
Mortality Rate (00:51:28) Kaplan-Meier Mortality Curve, Error Bars
& Significance, Statistical Power (01:02:23) Hazard Ratios,
Censoring (01:09:00) Metformin Advantage?, Variables, Interventions
Testing Program (01:16:02) Berberine, Acarbose, SGLT2 Inhibitors
(01:23:48) Blood Glucose & Energy Balance; Caloric Restriction,
Aging Biomarkers (01:32:22) Tool: Reading Journal Articles, 4
Questions, Supplemental Information (01:38:10) Article #2, Belief
Effects vs. Placebo Effect (01:45:22) Nicotine Effects (01:51:07)
Nicotine Doses & Belief Effects, fMRI Scan (02:00:07)
Biological Effects, Dose-Dependent Response & Belief Effects
(02:05:14) Biology & Beliefs, Significance, Dopamine Response,
Non-Smokers (02:10:57) Dose-Dependence & Beliefs, Side Effects,
Nocebo Effect (02:19:06) Zero-Cost Support, YouTube Feedback,
Spotify & Apple Reviews, Sponsors, Momentous, Neural Network
Newsletter, Social Media Disclaimer Learn more about your ad
choices. Visit megaphone.fm/adchoices