Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer

In this journal club episode, my guest is Dr. Peter Attia, M.D., a
Stanford and Johns Hopkins-trained physician focusing on healthspan
and lifespan and the host of The Drive podcast. We each present a
peer-reviewed scientific paper chosen because it contains novel,
interesting, and actionable data. First, we discuss a paper on how
bright light exposure at sunrise and throughout the day and dark
exposure at night independently improve mental health and can
offset some of the major symptoms of mental health disorders such
as depression and anxiety. Then, we discuss an article that
explores a novel class of immunotherapy treatments to combat
cancer. We also discuss some of the new data on low-calorie
sweeteners and if they are safe. This episode should be of interest
to listeners curious about maximizing their vitality and longevity
and to anyone seeking science-supported ways to improve mental
health and lifespan. Read the full shotes for this episode at
hubermanlab.com. Thank you to our sponsors AG1:
https://drinkag1.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Timestamps 00:00:00 Dr. Peter
Attia, Journal Club 00:02:56 Sponsors: LMNT & Waking Up
00:07:14 Light, Dark & Mental Health; Retina 00:11:16 Outdoor
vs. Indoor Light, Cataracts, Sunglasses 00:16:17 Tools: Sunrise
& Sunsets, Circadian Rhythm; Midday Light 00:24:55 Tools: Night
& Light Exposure; Waking Before Sunrise 00:31:05 Article #1,
Light/Dark Exposure & Mental Health 00:32:36 Sponsor: AG1
00:38:18 Odds Ratio, Hazard Ratio 00:45:43 Night vs. Daylight
Exposure, Mental Health Disorders 00:51:35 Major Depression &
Light Exposure; Error Bars & Significance 01:00:39
Prescriptions; Environmental & Artificial Light; Red Lights
01:08:14 Nighttime Light Exposure; Sleep Trackers & Belief
Effects 01:13:54 Light Directionality, Phone, Night 01:17:21 Light
Wavelengths & Sensors; Sunglasses 01:20:58 Hawthorne Effect,
Reverse Causality, Genetics 01:26:26 Artificial Sweeteners,
Appetite 01:31:16 Natural Light Cycles, Circadian Rhythm &
Mental Health 01:39:53 Article #2, Immune System & Cancer
01:43:18 T-Cell Activation; Viruses 01:50:41 Autoimmunity; Cancer
& Immune System Evasion 02:00:09 Checkpoint Inhibitors, CTLA-4
02:06:45 Anti-CTLA-4 Study Drug Ipilimumab, Melanoma 02:12:07
Patient Population, Randomization, GP100 02:18:09 Response Rate
02:22:52 Overall Survival & Response 02:28:38 Median Survival
vs. Overall Survival, Drug Development 02:35:45 Gender & Dose
02:40:32 Adverse Events; Autoimmunity 02:46:42 Pancreatic Cancer;
Aging & Immune System Health 02:53:57 Melanoma; Lynch Syndrome,
Keytruda 02:58:43 Immunotherapy & Cancer Treatment; Melanoma
Risk 03:06:26 Zero-Cost Support, Spotify & Apple Reviews,
YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network
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