How to Optimize Cognitive Function & Brain Health | Dr. Mark D'Esposito

In this episode, my guest is Dr. Mark D'Esposito, M.D., a
neurologist and professor of neuroscience and psychology at the
University of California, Berkeley. We discuss the brain mechanisms
underlying cognition and the forms of memory required for focus,
productivity, planning and achieving goals, and learning. We
discuss neurochemicals such as dopamine and acetylcholine and how
they can be leveraged to improve cognitive functioning. We also
discuss concussion, traumatic brain injury (TBI), Alzheimer's, and
Parkinson's disease, and ways to restore or slow cognitive decline
by using pharmacologic, lifestyle and behavioral protocols. This
episode provides a modern understanding of cognition and memory and
actionable tools to optimize brain health and function. For show
notes, including referenced articles and additional resources,
please visit hubermanlab.com. Thank you to our sponsors AG1:
https://athleticgreens.com/huberman LMNT:
https://drinklmnt.com/hubermanlab Waking Up:
https://wakingup.com/huberman Timestamps (00:00:00) Dr. Mark
D’Esposito (00:02:08) Sponsors: Maui Nui, Joovv & Eight Sleep
(00:06:23) Brain & Frontal Lobes, Prefrontal Cortex, Executive
Function (00:10:31) Frontal Lobe Development, Children (00:14:12)
Rules, Context & Impulse Control; Learning & Goals
(00:21:45) Focus, Improving Executive Function (00:26:04)
Connections & Top-Down Signals (00:29:02) Sponsor: AG1
(00:30:29) Frontal Lobe Injury; Emotional Regulation (00:37:26)
Smartphones, Social Media (00:44:37) Working Memory, Dopamine
(00:52:59) Sponsor: LMNT (00:54:22) Dopamine Levels & Working
Memory, Cognitive Tasks, Genetics (01:00:03) Bromocriptine &
Working Memory, Dopamine (01:06:21) Guanfacine, Neurotransmitter
Levels, Pupil Dilation & Biomarker Tests (01:12:46)
Bromocriptine, Olympics; Pharmacology & Cognitive Function,
Adderall (01:19:27) Concussion, Traumatic Brain Injury (TBI)
(01:25:22) Sleep, TBI, Concussion & Executive Function; BrainHQ
(01:31:57) Aging & Frontal Executive System; Brain Health
(01:39:26) Tools: Brain Health & Boosting Executive Function,
Books (01:47:26) Alzheimer’s Disease, Genetics, Pharmacology
(01:51:48) Parkinson’s Disease, L-Dopa; Coping with Alzheimer’s;
Nicotine (01:58:37) Estrogen & Dopamine, Cognition; Tool:
Physical Exercise (02:04:43) Tool: Mindfulness Meditation &
Executive Function (02:10:31) Brain Networks; Modularity (02:17:08)
Modularity, Brain Indices (02:22:53) Psilocybin; Transcranial
Magnetic Stimulation (02:30:16) Zero-Cost Support, Spotify &
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