Are Psychedelics The Solution To The Opioid Crisis? with Deborah Mash

This episode is brought to you by Cozy Earth, InisdeTracker, and
Rupa Health. If you or a loved one struggle with addiction, this is
an episode you’re going to want to listen to. Many of our current
pharmaceuticals stem from compounds discovered in plant medicines.
And many beneficial plants that were discovered decades ago still
have huge potential for changing modern medicine—ibogaine is one of
them. Today on The Doctor’s Farmacy, I’m excited to sit down with
Dr. Deborah Mash to discuss the use of the African plant ibogaine
and its metabolite, noribogaine, in the treatment of addiction and
how it could impact the devastating opioid epidemic.  Dr.
Deborah Mash is one of the world's foremost experts on ibogaine.
She is the CEO and Founder of DemeRx Inc., a clinical-stage drug
development company advancing ibogaine and its active metabolite
noribogaine for the treatment of opioid use disorder. DemeRx has
partnered with ATAI Life Sciences—a global biotech platform with a
special focus on psychedelic medicine—to develop ibogaine for those
suffering from opioid use disorder. Building on the extensive human
data available around ibogaine, DemeRx and ATAI are conducting a
Clinical Phase I/II trial in opioid-dependent patients. This
landmark trial will advance screening procedures, dosing
guidelines, and best practices for opioid withdrawal management and
relapse prevention.   This episode is brought to you by
Cozy Earth, InisdeTracker, and Rupa Health. Cozy Earth makes the
most comfortable, temperature-regulating, and nontoxic sheets on
the market. Right now, get 40% off your Cozy Earth sheets. Just
head over to cozyearth.com and use code MARK40. InsideTracker is a
personalized health and wellness platform like no other. Right now
they’re offering my community 20% off at insidetracker.com/drhyman.
Rupa Health is a place where Functional Medicine practitioners can
access more than 2,000 specialty lab tests from over 20 labs like
DUTCH, Vibrant America, Genova, and Great Plains. You can check out
a free, live demo with a Q&A or create an account at
RupaHealth.com. Here are more details from our interview (audio
version / Apple Subscriber version): The long history of ibogaine’s
ethnobotanical and ethnopharmacological use (7:01 / 4:10)  The
power of ibogaine to reset opioid tolerance and bypass many
withdrawal symptoms in a single dose (15:41 / 8:11)  How
ibogaine works (20:59 / 14:15)  Using ibogaine to protect
against future relapse (26:09 / 19:25)  Efforts to understand
the importance of ibogaine’s psychedelic effects (30:05 /
24:54)  Assessing the success rates of recovery and relapse
prevention from ibogaine treatment (37:49 / 34:02) 
Understanding the underlying drivers of addiction for better
recovery and relapse treatment (41:46 / 37:55)  The concept of
“psychoplastogens” and turning on synaptic plasticity in the brain
(51:44 / 47:52)  Humanity’s relationship to plants and plant
medicines (57:25 /  53:34)  Risks associated with and
considerations for seeking ibogaine treatment (1:03:24 / 59:37)
Learn more about Dr. Mash’s work at demerx.com.