Dr. Nir Barzilai: Can This Drug Slow Aging? The Science Behind Metformin

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Ad-free Episodes & Dr. Hyman+ Audio Exclusives Dr. Nir Barzilai
is a geroscientist, Chaired Professor of Medicine and Genetics, and
the founder and principal investigator of the Einstein Nathan Shock
Center and the Glenn Center for Excellence in Biology of Aging. He
also studies families of centenarians that have provided genetic
and biological insights on the protection against aging—with
several drugs developed based, in part, on these paradigm-changing
studies. He is also leading the TAME (Targeting/Taming Aging with
Metformin) trial to prove to the FDA that aging can be delayed and
to allow for next-generation interventions.  This episode is
brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty
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off a 90-day starter kit subscription. Just visit Fatty15.com and
use code DRHYMAN10 to get started. In this episode we discuss
(audio version / Apple Subscriber version): The hallmarks of aging
(9:01 / 7:10) What causes the hallmarks of aging? (15:40 / 13:49)
Dr. Barzilai’s research on centenarians (23:16 / 21:25) Why living
to 100+ years is good for the economy (24:54 / 23:03) What enables
someone to live to 100 years old? (29:30 / 25:20) Taking growth
hormone and Metformin have different effects based on your age
(36:58 / 32:48) The connection between HDL cholesterol and
longevity (43:36 / 39:26) Dr. Barzilai’s research on Metformin
(56:23 / 52:13) How Metformin works in the body and on muscle
growth (1:04:51 / 1:00:41) Dr. Barzilai’s personal longevity
(1:42:05 / 1:37:55) Learn more about the Longevity Genes Project
and the TAME Trial.  Get a copy of Age Later: Health Span,
Life Span, and the New Science of Longevity