Zum Einfluss repetitiv duodenal applizierter Aktivkohlegaben auf die Elimination von intravenös verabreichtem Paracetamol (N-Acetyl-para-aminophenol)
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vor 17 Jahren
Influence of repetitive duodenal application of activated charcoal
on the elimination of the elimination of intravenously applied
acetaminophen (N-Acetyl-para-aminophenol) The influence of the
repeated administration of activated charcoal on elimination of
intravenously injected acetaminophen was investigated in an in-vivo
model of anaesthetized rats. 40 rats were randomized and divided
into four groups of 10 animals, respectively. Concentration of
14C-marked acetaminophen and its metabolites was measured in
plasma, urine and small intestine irrigation samples of all
animals. To measure the influence of activated charcoal on
elimination of acetaminophen, the small intestine of one half of
the animals (n=20) was perfused with activated charcoal dissolved
in polyethylene glycol (PEG) (= gastrointestinal dialysis), the
small intestine of the other half (n=20) was perfused just with
PEG. In order to answer the question whether activated charcoal
interrupts enterohepatic circulation, half of the rats treated with
activated charcoal and half of the PEG-treated animals (n=10,
respectively) were subject to bile duct cannulation; the
externalized bile was then quantified for acetaminophen. During a
testing period of 3.5 hours, in the ileal effluent of animals with
physiological bile flow, we detected ca. 20% of the dose
administered originally; in the animals subject to cannulation, we
found about 7%. 13% of acetaminophen and metabolites were found in
the externalized bile. Activated charcoal did not influence the
exsorption of acetaminophen into the small intestine. Terminal
half-life in blood ranged from 35-51 minutes, there was no
statistically significant difference between the groups (P=0.152).
Neither did the Area under curve (AUC) – ranging from 2.6 to 3.3
g/min./l. – show significant variation between groups (P=0.392).
Concentration of acetaminophen in liver and kidney samples, which
were removed post mortem, was very low, ranging from 0.02 to 0.6%
of the dose originally administered. Excretion of acetaminophen
into urine varied widely (31-56%), correlating with diuresis. The
absence of an effect of activated charcoal on elimination of
acetaminophen and metabolites may have been caused by exsorption of
insufficient amounts into the intestinal lumen.
on the elimination of the elimination of intravenously applied
acetaminophen (N-Acetyl-para-aminophenol) The influence of the
repeated administration of activated charcoal on elimination of
intravenously injected acetaminophen was investigated in an in-vivo
model of anaesthetized rats. 40 rats were randomized and divided
into four groups of 10 animals, respectively. Concentration of
14C-marked acetaminophen and its metabolites was measured in
plasma, urine and small intestine irrigation samples of all
animals. To measure the influence of activated charcoal on
elimination of acetaminophen, the small intestine of one half of
the animals (n=20) was perfused with activated charcoal dissolved
in polyethylene glycol (PEG) (= gastrointestinal dialysis), the
small intestine of the other half (n=20) was perfused just with
PEG. In order to answer the question whether activated charcoal
interrupts enterohepatic circulation, half of the rats treated with
activated charcoal and half of the PEG-treated animals (n=10,
respectively) were subject to bile duct cannulation; the
externalized bile was then quantified for acetaminophen. During a
testing period of 3.5 hours, in the ileal effluent of animals with
physiological bile flow, we detected ca. 20% of the dose
administered originally; in the animals subject to cannulation, we
found about 7%. 13% of acetaminophen and metabolites were found in
the externalized bile. Activated charcoal did not influence the
exsorption of acetaminophen into the small intestine. Terminal
half-life in blood ranged from 35-51 minutes, there was no
statistically significant difference between the groups (P=0.152).
Neither did the Area under curve (AUC) – ranging from 2.6 to 3.3
g/min./l. – show significant variation between groups (P=0.392).
Concentration of acetaminophen in liver and kidney samples, which
were removed post mortem, was very low, ranging from 0.02 to 0.6%
of the dose originally administered. Excretion of acetaminophen
into urine varied widely (31-56%), correlating with diuresis. The
absence of an effect of activated charcoal on elimination of
acetaminophen and metabolites may have been caused by exsorption of
insufficient amounts into the intestinal lumen.
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