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Season 4 – Episode 5: When we eat matters – food, metabolism, and the body clock

31 Minuten
We often hear about what and how much we should eat. But does when we eat matter too?

In this episode of Light O'Clock, we speak with Dr Emily Manoogian about how our metabolism changes throughout the day and what this means for our eating habits.

We explore whether eating more in the morning is better than eating late in the evening, how meal timing interacts with our internal body clocks, and what the science really says about intermittent fasting and time-restricted eating.

Plus, we discuss some simple, evidence-based tips for timing our meals, without having to completely rearrange our daily routines.

Links and references:

Review paper: Circadian rhythms, time-restricted feeding, and healthy aging

Review paper: When to Eat: The Importance of Eating Patterns in Health and Disease

Season 4 – Episode 4: Lighting in the first days of life – Circadian care in neonatal units

22 Minuten
In this episode, we speak with Roos Bos, a PhD researcher in the Netherlands studying how light exposure affects preterm infants in the neonatal intensive care unit (NICU).

Roos breaks down:

How the circadian system develops before and after birth

How the NICU environment differs from the rhythmic environment of the womb

Why light-dark cycles may matter during this sensitive period of development and what we currently know about lighting interventions in the NICU

How time cues, such as feeding, breast milk and temperature could help support developing circadian rhythms

Links and references:

Paper: Skin-to-skin contact improves sleep stability in preterm infants

Paper: Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit

Season 4 – Episode 3: Light therapy in cancer care

26 Minuten
Cancer and its treatment are often accompanied by symptoms such as fatigue, sleep problems, low mood, and cognitive difficulties. These symptoms frequently occur together, and circadian disruption may be one factor contributing to their development and persistence.

In this episode of Light O’Clock, we speak with Lisa Maria Wu about how cancer and its treatments can affect circadian rhythms and how these changes are measured. We also discuss bright-light therapy and other behavioural approaches that may help strengthen circadian rhythms, as well as what research is still needed before these strategies become part of routine cancer care.

Links and resources:

https://doi.org/10.3389/fonc.2022.1009064

10.1002/pon.3553

Season 4 – Episode 2: The best time for a vaccine? Circadian rhythms and immunity

32 Minuten
Is there a best time for a vaccine? In this episode of Light O'Clock, we speak with Dr Cathy A. Wyse about whether the time of day when we receive a vaccine can influence how we respond to it.

We first discuss how circadian rhythms shape the immune system, how vaccines work, and the difference between vaccine response (e.g., antibody levels) and vaccine effectiveness (i.e., protection against infection or disease). We then discuss why the current evidence remains mixed and how factors such as chronotype, sleep, age, sex, prior immunity, and vaccine type may influence results.

Paper reference: https://doi.org/10.1177/07487304241232447

The key message: the immune system is rhythmic, so timing could matter -- but the evidence is not yet strong enough to recommend one specific time of day for vaccination. For now, the most important advice remains: get vaccinated when you can.

Season 4 – Episode 1: Why biological timing matters in medicine

36 Minuten
In the first episode of Season 4, we start with the foundations of circadian medicine.

Together with our guest Henrik Oster, we take a tour through the circadian system and ask what biological timing has to do with health and disease. We discuss how the body coordinates different physiological and behavioural functions across the 24-hour day, what can happen when internal rhythms become disrupted, and why timing may matter in medicine.

We then introduce three key ideas in circadian medicine: exploiting the clock to optimise the timing of treatments, targeting the clock as part of therapy, and detecting the clock to better personalise healthcare. Finally, we examine the current state of the field, the challenges of integrating circadian principles into clinical practice, and the future of circadian medicine.

This episode sets the stage for the rest of the season, where we will explore specific areas of circadian medicine in more detail – from vaccines and cancer care to neonatal health, metabolism, exercise, and shift work. Stay tuned!
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Über diesen Podcast

We break down the science behind circadian rhythms so you can be enlightened. In each podcast episode, we chat with experts in the field about a variety of topics, spanning from the effects of light on our biology and how it can be used for the treatment of psychiatric disorders and beyond. Contact us: lightoclock@tuebingen.mpg.de Website: https://tscnlab.org/podcast
Urheberangabe
Translational Sensory & Circadian Neuroscience Unit (MPS/TUM/TUMCREATE)
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Ø 28 Min.
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Monatlich
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vor 2 Std.
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vor 2 J.
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