Challenging HSAB: Reactive Molecules and Nucleophiles

In this episode of Innovate and React, I am talking with Justus
Reitz, a chemist from TU Dortmund University, about the limitations
of the HSAB (Hard and Soft Acids and Bases) concept in predicting
reaction outcomes. We explore an alternative approach using the
nucleophilicity scale developed by the Mayr group, which offers a
more accurate prediction method. Justus shares insights from his
PhD research on stabilizing highly reactive molecules, particularly
the synthesis and stabilization of diazoalkenes. We discuss how the
Mayr nucleophilicity scale can facilitate understanding and
controlling chemical reactions, bridging the gap between
theoretical concepts and practical applications. For more check out
innovateandreact.com