Promise and Controversies: State of the State of Longevity Science with Matt Kaeberlein, PhD

It's important to me to include a variety of voices in the sphere
of aging and longevity, and Matt Kaeberlein PhD is certainly one
that I appreciate for his tempered and rational arguments. I value
his insights and his work with other scientists who are tussling
with the challenging questions and research interpretations in this
field. We are at this extraordinary inflexion point where
scientists are debating the very definition of aging itself, which
has important implications for how we then measure and study it.
Dr. Kaeberlein shares his thoughts on this as well as the latest on
longevity interventions such as rapamycin, metformin, intermittent
fasting, and caloric restriction. Find out why he thinks we'll
always hit a wall with moving the needle on lifespan, and why
healthspan is such an important target. I think you will find this
conversation illuminating and useful. An additional note for any of
my listeners/readers who have been tracking the various discussions
around the utility of epigenetic clocks and other measures of
aging: I personally very much believe in epigenetics, even as the
field continues to evolve. The foundation of this traces back to my
beginnings in this field, working under my mentor Richard Lord PhD,
who taught me that as scientists and clinicians we have no choice
but to embrace uncertainty. No laboratory tests are as precise as
many of us would like to think they are - microbiome, organic acid,
nutrient testing, those foundational tools of functional medicine
that we are very comfortable using, included. This applies to
standard labs too - I recently received a notification from one of
the two biggest labs in the US stating that, due to a change in the
testing instrument used, values for red cell indices (the oldest
tests on the planet!) would be altered compared to prior results.
As clinicians we have to grapple with uncomfortable uncertainty in
medicine every single day - from that reality we still have to move
forward and make the best clinical decisions we can. Epigenetic age
testing is simply another tool in the mix that can add value to
understanding a patient's picture, and we can use it even as we
interpret it with a similar acknowledgement of uncertainty. If you
would like to add your thoughts to this discussion, please share
below. - DrKF

Check out the show notes at
https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list
of links and resources.
GUEST DETAILS

Matt Kaeberlein, PhD, CEO, Optispan https://tinyurl.com/2r89rvdd


Email Matt@optispan.life
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