010 Dr. David Sinclair – Why We Age and Why We Don't Have To

00:52 – Introducing today’s guest, David Sinclair


06:28 – David’s origin story


08:38 – Why we age


11:17 – The genome and epigenome


13:00 – The piano metaphor


15:51 – Sirtuins explained


21:59 – Other environmental stressors that sirtuins detect


25:11 – Hormesis defined


28:13 – How NAD+ and its precursors combat aging


35:11 – Dr. Stephanie brings up a specific story from Dr. David’s
book


38:40 – Friedreich's Ataxia


39:27 – Benefits of resveratrol


45:11 – Horvath's Clock and measuring age accurately


47:58 – The backup copy of the epigenome


53:44 – Anti-aging technologies on the horizon


55:07 – Other anti-aging best practices


56:47 – Dr. Stephanie suggests a new sequel to the Avengers
franchise


57:48 – Dr. Stephanie thanks Dr. David for joining the show


58:21 – Dr. David shares with the audience where they can find
the cheat sheet in his book


58:48 – Where listeners can follow Dr. David


1:00:00 – Where listeners can follow Dr. Stephanie and subscribe
to her newsletter


TWEETABLE QUOTES


“I wrote the book because there’s a lot of really interesting
technology and things people can do in their daily lives, I
believe, to live significantly longer and healthier. But, I also
wanted to start the conversation because I felt no one was really
saying the kinds of things that I was saying.” (08:15)


“I think that the major driver of aging, put simply, is a loss of
information.” (10:19)


“I think it’s worth clarifying that the sirtuins are protectors
of our bodies, but they can also cause aging by being distracted
too much.” (25:11)


“It’s all about being uncomfortable. Our bodies would much rather
sit in a chair and eat popcorn. There’s a whole industry based on
that.” (26:19)


“I like to joke that scientists like to fight because the stakes
are so low.” (42:41)


“We can predict, very accurately, how old someone is
biologically. And that’s not so much related to birthday candles.
It’s more about how you’ve lived your life. Twenty percent of
your age will be genetic and eighty percent will be how you’ve
lived.” (46:59)


“What I don’t know is how to bring people back from the dead, but
I think we’re getting close to being able to keep people alive in
a healthy way for much longer.” (57:31)


LINKS MENTIONED


Better! Website


Dr. Stephanie’s Website


Dr. Stephanie’s Twitter – @dr_stephanie


Dr. Stephanie’s Instagram – @dr.stephanie.estima


Dr. Stephanie on LinkedIn


Dr. David’s Book - Lifespan: Why We Age―and Why We Don't Have To


Dr. David’s Website


Dr. David’s Instagram – @davidsinclairphd


Dr. David’s Twitter – @davidasinclair


Dr. David’s Facebook


ADDITIONAL RESOURCES FOR THIS PODCAST


In animal models, more NAD is better


At least when it is paired with exercise


The Mathematical Theory Of Aging


The Horvath Clock


Reversal Of Aging & Cellular Reprogramming


Resveratrol effects 1 


Resveratrol effects 2


NMN & lifespan in mice


David’s Newsletter


David’s book


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