How to Fix Your Gut & Heal Your Body with Dr. Vincent Pedre

Meet Vincent M. Pedre the Medical Director of Pedre Integrative
Health and President of Dr. Pedre Wellness. Dr. Pedre is a
Board-Certified Internist and Functional Medicine Certified
Practitioner in private practice in New York City since 2004. His
philosophy and practices are a blend of both Western and Eastern
medical traditions. He is a Clinical Instructor at the Mount
Sinai School of Medicine, as well as certified in yoga and
Medical Acupuncture.


Links for this episode:


Fermented-food diet increases microbiome diversity, decreases
inflammatory proteins, study finds


The Importance of Food for Endotoxemia and an Inflammatory
Response


GutSmartProtocol.com


The GutSMART Quiz


Instagram @drpedre


Episode Description


00:07:30 - The Gut-Skin Connection, 
The gut and skin originate from the same cells in embryology,
making their connection significant. Patients with skin issues
may benefit from a functional medicine approach that considers
the connection between gut health and skin issues, like hives,
acne, psoriasis, and dermatitis.

00:11:45 - Celiac Genetics and Gluten-Free Diets, 
Celiac genetics are prevalent in people of Irish descent, and
eliminating gluten from the diet can alleviate hives and other
skin issues. A functional medicine approach can provide a
solution for patients who have seen dermatologists without any
results.

00:13:35 - Good and Bad Bacteria in the Gut, 
The gut microbiome is a complex ecosystem that includes a set of
bad bacteria that serve a purpose and keep the system in balance.
Opportunistic bacteria can flourish in environments where the
diet is not optimal, leading to gut-centric and non-gut-centric
issues.

00:16:23 - The Gut Microbiome of Indigenous Tribes, 
Dr. Pedre discusses the gut microbiome of indigenous tribes and
how it differs from Westerners. Indigenous tribes consume a
high-fiber diet, and their gut microbiome has adapted to digest
difficult-to-digest fibers. 

00:20:20 - The Importance of Gut Microbiome
Adaptation, 
Dr. Pedre stresses the importance of slowly introducing changes
to the gut microbiome. A sudden change can lead to bloating and
discomfort. 

00:25:05 - The Gut-Airway Connection, 
Dr. Pedre explains how the gut microbiome is connected to upper
respiratory infections. Antibiotics can disrupt the gut
microbiome and immune system, leading to recurrent infections.
Pregnancy can ramp up the immune system, but can also suppress
certain parts to protect the baby.

00:29:35 - Lipopolysaccharides and Metabolism, 
Dr. Pedre explains that Lipopolysaccharides (LPs), also known as
endotoxins, are released by gram-negative bacteria and can be
absorbed into the body. LPs levels increase after meals high in
fat, especially saturated and hydrogenated fats. LPs can affect
metabolism and insulin sensitivity.

00:33:42 - Microbiome and Leaky Gut, 
Dr. Pedre explains how an unfavorable microbiome and leaky gut
can lead to the absorption of lipopolysaccharides and cause many
health issues, such as weight gain, muscle aches, fatigue, and
depression. Keeping a food, mood and poop journal can help
identify patterns and triggers.

00:35:34 - Timeline for Food Sensitivities, 
Dr. Estima and Dr. Pedre discuss the importance of keeping a food
journal to identify patterns of food sensitivities. They explain
how sensitivities can have a threshold effect, where one exposure
may be fine, but a second exposure can cause symptoms. Other
factors such as stress, sleep, and food combinations can also
impact sensitivities.

00:39:35 - Stress and Gut Health, 
Dr. Pedre explains how stress can affect the gut microbiome, gut
permeability, and vagal tone. High cortisol levels from stress
can alter the gut ecosystem, leading to more yeast in the gut and
sugar cravings. 

00:43:39 - Behavioral Changes Caused by Stress, 
Dr. Estima and Dr. Pedre discuss how stress can drive behavioral
changes such as cravings for sugar and comfort foods. 

00:49:39 - The Power of Soil and Dirt, 
Dr. Pedre emphasizes the importance of soil and dirt for our
microbiome. Exposure to organic soil without toxins can magnify
our gut microbiome diversity, as seen in the Hadza tribe.

00:55:05 - Diversity vs. Eating the Rainbow, 
Dr. Pedre discusses a Stanford study that compared a high fiber
diet to a high fermented foods diet. The high fiber diet did not
show a significant increase in microbiome diversity, while the
fermented foods diet did. Diversity is the holy grail, but it's
not a one-size-fits-all approach.

00:59:00 - The Role of Fiber and Fermented Foods, 
The study found that fermented foods had a significant impact on
microbiome diversity and reduced inflammation. While fiber had a
smaller impact, it helped to regulate the immune
system. 

01:03:27 - Gut Disruptors, 
Dr. Pedre notes that alcohol is a significant gut disruptor.
Other factors, such as stress, lack of sleep, and processed
foods, can also impact gut health. A personalized approach to
healing the gut is necessary, with fermented foods and fiber as
cornerstones, but with consideration of individual
circumstances.

01:06:18 - Dairy and its impact on gut health, 
Dr. Pedre discusses the impact of dairy on gut health,
highlighting that it can cause constipation and trigger food
sensitivities due to lactose and dairy protein
intolerance. 

01:07:35 - Fecal matter transplant, 
Dr. Estima and Dr. Pedre discuss fecal matter transplant as a
possible treatment for gut-related conditions such as Crohn's
colitis and ulcerative colitis. While it is not yet approved for
many indications, it has shown promise in experimental treatments
for food sensitivities and autism in the microbiome
community.

01:11:06 - Protecting the microbiome, 
Dr. Estima and Dr. Pedre stress the importance of protecting the
microbiome throughout life, from birth to adulthood and into old
age. They discuss the negative impacts of persistent antibiotic
use and emphasize the need to foster microbial diversity through
diet, exposure to nature, and limiting exposure to mass
agriculture.

01:13:32 - Seeking microbial diversity, 
Dr. Pedre encourages individuals to seek microbial diversity in
their gut by avoiding antibiotics as much as possible, only using
them when necessary. He advises fostering microbial diversity
through a healthy diet, exposure to nature, and gardening. He
notes that microbial diversity is a key factor in the health of
centenarians.


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