Bleeding and coagulation in Trauma with Ross Davenport

In this conversation we will examine the principles of
coagulopathy and novel approaches to coagulopathy within
pre-hospital care. We will examine the utility of fibrinogen
concentrate, the distinct features of fibrinogen concentrate with
cryoprecipitate, its longevity of use compared to other blood
products, how you constitute fibrinogen concentrate for use in
the pre-hospital environment amongst other topics. 


 


To do this I have Ross Davenport with me, Ross is a
Consultant Trauma & Vascular Surgeon at the Royal
London hospital in the UK. He is also a Senior Lecturer in
Trauma Sciences and has previously worked in prehospital care for
both London and Essex & Herts Air Ambulance. His research has
focused on trauma-induced coagulopathy, acute response to injury
and the treatment of major trauma haemorrhage. His work in
traumatic coagulopathy and massive transfusion, inflammation and
organ dysfunction has had international renown. In the
episode we examine:


·      Coagulation and the
pre-hospital evidence 


·      Are we getting a handle on
hypothermic induced coagulopathy 


·      What is fibrinogen
concentrate and its mechanism of action?


·      How it differs from
cryoprecipitate and whether we still need cryoprecipitate.


·      What the initial empirical
research shows from CRYOSTAT 2 research.


·      It’s robustness within
pre-hospital environments and how you reconstitute it for
pre-hospital use. 


·      Current trials with
Fibrinogen concentrate and early indications of
effectiveness. 


·      ROTEM/thromboelastometry
markers of effectiveness 


·      When to give it in the
patient journey? 





Please enjoy this episode.