TFS#90 - Jacob George On Drug Research & Development, Hepatitis Cures, Blue Zone Diet w/ Renowned Hepatologist & Liver Research Scientist Prof.

Professor Jacob George is a renowned hepatologist and liver
research scientist who studies the causes of and mechanisms for
the development of liver disease and liver cancer. 


Professor George’s work has made significant contributions to
clinical practice. His team first identified the role of
interferon lambda 3 gene polymorphisms for predicting treatment
response in chronic hepatitis C, and a second gene polymorphism
that interacts with interferon lambda 3. These discoveries are
considered major advances in the field and the finest examples of
‘personalized medicine'. 


Professor George was an author of the groundbreaking study of
combination telaprevir, pegylated interferon, and ribavirin
therapy for hepatitis C, which changed the landscape of hepatitis
C treatments, heralding the era of direct-acting antivirals. His
work identifying insulin resistance as the universal underlying
pathophysiological abnormality in fatty liver disease underpins
the majority of research on this condition and is the cornerstone
of current therapy (lifestyle intervention; exercise;
insulin-sensitizing agents). He also first described the
association between hepatitis C and insulin resistance. 


Professor George is an advisor to Hepatitis Australia, the
Transfusion Related AIDS and Infectious Diseases Service, and at
state and national levels, on viral hepatitis. He oversees
research for the Asian Pacific Association for the Study of
Liver. He is a Fellow of the American Association for the Study
of Liver Disease. 


Professor Jacob George MBBS, FRACP, Ph.D.,
FAASLD





CHAPTERS:


00:00 Intro


00:20 Meet Prof. Jacob George


01:00 Professors In The Hospital


02:30 KPIs For Delivering Clinical Care


03:40 Research & Academic KPIs


05:00 Medical Research Method


06:10 Mice Lab Testing


08:30 How Washing Hands Saved Lives


09:40 Pathophysiology Cycle


11:40 Curing Hepatitis C


12:30 Designing Drugs


14:40 Growing Virus In The Lab


16:00 Hepatitis B Breakthroughs


18:40 Virus Reservoir Forms


20:40 Eliminating Dormant Virus


22:00 Early Phase Human Studies


24:30 Long Term Side Effects


24:50 Thalidomide Scandal


26:00 Clinical Trials


27:00 Post Marketing Research


29:05 Cost vs Benefit


29:45 Independent Experts


31:55 The Covid Vaccines


33:15 Do Masks Work?


35:30 Does Vaccine Works?


37:20 Personal Risk Factors


37:55 The Old Man’s Friend


39:05 The Immune Response


41:30 The Immune System


43:05 Natural Immunity


44:30 Immune System Memory


46:15 Average Human Lifespan


47:00 Healthy Aging


48:20 Cancer Development


50:50 The Blue Zone Diet


53:35 Social Constructs On Food Behavior


55:20 The Agricultural Age


57:30 Nutritional Ecology


59:25 Child Rearing Experiment


01:02:15 Knowledge Dissemination


01:04:10 Just A Speck


01:04:35 Outro