SPONSORED | The Critical Role Telomeres Provide in Aging, Senescence, and Disease

It’s always a pleasure to tap into Dr. Raffaele’s brain, and in
this podcast he doesn’t disappoint. In fact, his practical
contextualization of where we are with anti-aging medicine might
just be one of the smartest you’ve heard yet. What is truly
remarkable about Dr. Raffaele is not just his grasp of the field
both scientifically and clinically, but his ability to apply a
nuanced approach that is tailored to each individual patient. After
all, as he eloquently points out, we must first figure out which of
the many components of aging needs improvement or correction, then
target our approach accordingly. The simplicity of that statement
belies his firm grasp of the complex landscape of anti-aging
assessments and interventions, as you’ll see. One of the important
topics that surfaced in our conversation is the role of telomere
length. Dr. Raffaele has been measuring telomeres in study cohorts
and in his patient population for well over a decade. Has looked at
well over 2,000 telomere length measurements, many of them
longitudinally. Not only that, but he has also integrated telomeres
alongside other biomarkers of aging, including DNA methylation
clocks, and tried-and-true metabolic markers such as lipids. So, if
you thought newer approaches to biological age assessment were
making telomeres and other assessments redundant, think again.
We’re entering a time where we must wrestle with how to incorporate
and act on all these important measures. ~DrKF