Decoding Aging: The Science Of Cellular Rejuventation With Dr. Vittorio Sebastiano

It was a career-defining (and perhaps life changing) moment when
Dr. Vittorio Sebastiano, a reproductive biologist by training,
realized that because we are able to create life, that same body of
information could be harnessed to create youth - that is, radically
reverse our biological aging process to a younger time point
without losing cellular identity. In 2014, he and his lab began
unpacking this epiphany. They made the radical decision to conduct
their investigations in human cells and tissue rather than in
rodents, with the expectation that such a start would be a better
bridge to human clinical trials. Flash forward a decade and Dr.
Sebastiano and his team stand poised to begin trials in humans. Dr.
Sebastiano is, in my opinion, one of the most extraordinary
scientists in the longevity space today who flies under the radar
of most of us in functional medicine. In this podcast - which is
actually two-in-one because I continued the conversation with him
on a second date - you’ll hear about the remarkable work they’re
undertaking at his lab. For example: They’ve created a biological
clock that encompasses the whole genome consisting of millions and
millions of CpG sites. They are able to clearly demonstrate the
reversal of bioage using their methodology - a cocktail of Yamanaka
factors plus, with clear time limits - which changes the epigenome
first, and in so doing influences all of the hallmarks of aging.
Teaser: they’ve identified one intervention routinely used in
clinical practice that influences their bio age clock in the same
way that their cocktail does. What is it? I was riveted with this
conversation, as I am sure you’ll be. Leave a review if you like
it, and - Yes - let me know what you think. I know this will prompt
deep questions for you, as it did for me. ~DrKF Check out the show
notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the
relevant links and resources.