Barry Sears (of Zone Diet Fame) on Lifetime Metabolic Health and Sourcing Omega-3s

I'm excited to welcome Dr. Barry Sears, the renowned creator of the
Zone Diet and a pillar in our field. Dr. Sears has not only
authored bestsellers but has also made incredibly important
contributions to clinical practice which we still rely on today: He
is, for instance, the scientist who put the use of the AA:EPA ratio
on the map. Dr. Sears provides elegant and accessible explanations
of the unassailable importance of diet in addressing inflammation,
metabolic health, chronic disease, and longevity, and the role that
fatty acids play in that milieu. And while he and I might not agree
that polyphenols need to be absorbed intact for benefit - there's
plenty of evidence that their postbiotic products are very
important players, especially in their interactions with the
epigenome - his concerns about the chemical structure of highly
concentrated fish oil supplements (with the potential for
isomerization, as he argues) has opened my eyes and is important,
without doubt. I think the jury is still out as to whether there is
a negative influence of isomerization in highly concentrated EPA
and DHA, but it's worthy of further investigation and (importantly)
is another factor in the argument for a whole-food approach. - DrKF

Check out the show notes at
https://www.drkarafitzgerald.com/fxmed-podcast/ for all the
relevant links and resources.


Guest information


Dr. Barry Sears, President, Inflammation Research Foundation
and CEO of Zone Labs.Inc.

Email: bsears@drsears.com

Website: http://www.drsears.com/

Zone Living Website: http://www.zoneliving.com/

Inflammation Research Foundation:
http://www.inflammationresearchfoundation.org/



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Show Notes


Dietary Control of Inflammation and Resolution -
https://tinyurl.com/vadkjzf7

The STRENGTH trial - https://tinyurl.com/282cz27m

OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/

REDUCE-IT Study -
https://clinicaltrials.gov/study/NCT01492361

ASCEND Study - https://ascend.medsci.ox.ac.uk

VITAL Study - https://www.vitalstudy.org/

Longitudinal Study - Multi-omics Biological Age Estimation
and Its Correlation with Wellness and Disease Phenotypes -
https://tinyurl.com/2p85yx5f