Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh

Even as we prioritize natural interventions in functional
medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer
sometimes life-changing support for those who have long struggled
with resistant overweight/obesity and high blood sugar. However,
there are side effects, including the risk of substantial muscle
loss and sagging, aged skin ("Ozempic face" as it's indelicately
known). It's a concern that hits home for me, considering the
pivotal role we know that muscle plays in overall health and
longevity.


In this New Frontiers podcast episode I welcome back Dr. Anurag
Singh to unravel the complexities of these issues. We explore the
interplay between metabolic health and muscle preservation,
touching on everything from the mechanisms of GLP-1 agonists and
their long-term effects on aging and sarcopenia, to the promising
potential of dietary and lifestyle interventions to counteract
negative effects. We consider the potential for one of my
all-time fave postbiotic epinutrients - Urolithin A - to assist
by supporting mitochondrial health and preserving/enhancing
muscle quality. This timely conversation is one you won't want to
miss. Tune in and please leave us a review wherever you listen to
New Frontiers. – DrKF


Check out our show notes
https://www.drkarafitzgerald.com/fxmed-podcast/
Guest information

Anurag Singh, MD, PhD
Chief Medical Officer at Timeline
Thank you to our sponsor

Timeline

Mitopure

Research from Timeline

care@timeline.com



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Listeners
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products. Head over to Timeline and use the code KARA10 at
checkout.
Show Notes

Study: Once-Weekly Semaglutide in Adults with Overweight or
Obesity https://tinyurl.com/y3c2ypkw

Pre-clinical trial (Recruiting): Effects of Urolithin A
Supplementation on Glucose Metabolism in Healthy Adults 55>=
Years Old...https://tinyurl.com/bdzfccr8 Study: Urolithin A
improves muscle strength, exercise performance, and biomarkers of
mitochondrial health in a randomized trial in middle-aged adults
https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of
Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model
KK-Ay/Ta Mice with Glucose Intolerance https://tinyurl.com/2jkhmu9w
Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity
Through Augmentation of Mitochondrial Function and Biogenesis
https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A
Supplementation on Muscle Endurance and Mitochondrial Health in
Older Adults A Randomized Clinical Trial
https://tinyurl.com/fscfdd85 Study: Direct supplementation with
Urolithin A overcomes limitations of dietary exposure and gut
microbiome variability in healthy adults to achieve consistent
levels across the population https://tinyurl.com/e6npdvyp Preprint
article: Topical application of Urolithin A slows intrinsic skin
aging and protects from UVB-mediated photodamage: Findings from
Randomized Clinical Trials https://tinyurl.com/2m2nzd56