Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects

Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412
(ε2), both invoking changes in the amino-acid sequence of the
apolipoprotein E (APOE) gene, have previously been tested for
association with multiple sclerosis (MS) risk. However, none of
these studies was sufficiently powered to detect modest effect
sizes at acceptable type-I error rates. As both SNPs are only
imperfectly captured on commonly used microarray genotyping
platforms, their evaluation in the context of genome-wide
association studies has been hindered until recently.