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  4. #825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More
#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

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Dr. Dominic D’Agostino (@DominicDAgosti2) is a
tenured associate professor in the Department of Molecular
Pharmacology and Physiology at the University of South Florida
Morsani College of Medicine and a Visiting Senior Research
Scientist at the Institute for Human and Machine Cognition.

This episode is brought to you by:

Helix Sleep premium
mattresses: https://HelixSleep.com/Tim (27%
off all mattress orders)

Momentous high-quality
creatine: https://livemomentous.com/tim (code
TIM for up to 35% off)

AG1 all-in-one nutritional
supplement: https://DrinkAG1.com/Tim
(1-year supply of Vitamin D plus 5 free AG1 travel
packs)

Timestamps:

[00:00:00] Start.

[00:14:43] Why I'm interested in ketogenic strategies for
neurodegenerative prevention.

[00:16:18] Mary and Steve Newport's ketone-linked temporary
cognitive improvements.

[00:18:18] A mechanisms overview for Alzheimer's/dementia.

[00:21:25] The immune system as longevity's "fifth horseman" —
and why metabolic control is key.

[00:22:04] How to measure ketones and GKI.

[00:23:00] Fasting vs. ketogenic diet.

[00:24:18] There's nothing fishy about sardine fasting.

[00:28:32] My hiatal hernia discovery and increased cancer risk
concerns.

[00:30:04] HSCRP as a superior biomarker to LDL for
cardiovascular risk.

[00:31:57] Glucose tolerance testing revelations and CGM
importance.

[00:31:57] Upgrading the metabolic machinery through keto without
getting bored.

[00:42:07] What do do if you, like Dom and me, are among the 30%
who suffer from cholesterol hyperabsorption.

[00:43:42] Dom's day-to-day diet regimen.

[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs,
and supplements.

[00:51:30] Supplementing for sleep disruption while fasting.

[00:55:41] Why Dom doesn't have misgivings about melatonin.

[00:59:15] Shingles prevention through fasting protocols.

[01:00:15] Immune system modulation: Innate vs. adaptive, vegan
vs. ketogenic.

[01:03:54] Dom at 50-something: Current meal timing and
composition.

[01:05:57] Blue zone observations: Greek and Sardinian longevity
habits.

[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and
fasted cardio.

[01:15:18] Ketone metabolic therapy for cancer.

[01:18:15] The metabolic psychiatry revolution.

[01:22:10] The soothing effects of hyperbaric oxygen and ketosis
on seizure sufferers.

[01:28:27] Metformin vs. berberine.

[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.

[01:34:58] NAD research: MIB-626 and stabilized forms for
mitochondrial health.

[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.

[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones,
vitamin D, melatonin.

[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious
Nutrition, veteran-focused research protocols, and other parting
thoughts.

*

Show notes for this
episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/

For show notes and past guests
on The Tim Ferriss Show,
please
visit tim.blog/podcast.

For deals from sponsors of The Tim
Ferriss Show, please
visit tim.blog/podcast-sponsors

Sign up for Tim’s email newsletter (5-Bullet Friday)
at tim.blog/friday.

For transcripts of episodes, go
to tim.blog/transcripts.

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