The Role of Mitochondrial Quality Control Pathways in Familial and Non-Familial Variants of Disease, with David Tumbarello

Join us today as we speak to Dr David Tumbarello, from the
University of Southampton, as he talks to us about his dynamic
and varied academic career that has taken him from New York, to
Southampton, stopping off at a number of places in between!!
David's lab currently focuses on understanding the cellular
mechanisms and molecular machinery required for subcellular
trafficking of membrane associated and cytosolic cargo via
endocytosis and autophagy. Knowledge of these mechanisms is
critical for understanding the molecular mechanisms of cancer and
neurodegenerative diseases , which stem from defects in various
membrane trafficking and cell signalling pathways.


Today we discuss one of David's lab's recent papers, published
June 2020, which looks at multiple mitochondrial quality control
pathways that exist to maintain the health of mitochondria, the
mitochondrial stress response and identify the interaction of
molecules associated with this response with E3 ubiquitin ligase
Parkin - involved in Parkinson's disease.





Read the paper here: https://eprints.soton.ac.uk/438725/


Find David on Twitter here: @DavidTumbarello





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