Dissecting the binding mechanisms of Transcription Factors to DNA with Dr Patrick CN Martin

Welcome to Episode 28 of The Genomics Lab! On today's episode we
talk to Dr.Patrick CN Martin who is a postdoctoral researcher at
the University of Copenhagen. He completed his PhD in Dr Radu
Zabets lab in 2020 where he investigated the binding mechanisms
of transcription factors to DNA. His research involved
development of an R package, ChIPAnalyser. A user-friendly,
versatile and powerful R/Bioconductor package predicting and
modelling the binding of TFs to DNA. ChIPanalyser performs
similarly to state-of-the-art tools, but is an explainable model
and provides biological insights into binding mechanisms of
transcription factors to DNA. His research focused on
investigating the binding mechanisms of three TFs that are known
architectural proteins CTCF, BEAF-32 and su(Hw) in three
Drosophila cell lines (BG3, Kc167 and S2). Aside from his
research, Patrick enjoys coding, astrophysics and is now working
in the exciting field of spatial transcriptomics! We also discuss
the use of clinical data in genomics research, learning to code
and bioinformatics. Hope you all enjoy! (See below for links)


Patrick's twitter: https://twitter.com/pcnmartin


Patrick's paper:
https://www.sciencedirect.com/science/article/pii/S2001037020304736?via%3Dihub


ChIPAnalyser Bioconductor package:
https://www.bioconductor.org/packages/release/bioc/html/ChIPanalyser.html