SIBO and Detoxification with Dr Chris Shade

In this episode Dr Nirala Jacobi is in conversation with Dr
Christopher Shade. Dr Shade is the CEO and founder of Quicksilver
Scientific, a lab that specialises in the environmental,
biological, and analytical chemistry of mercury and all of its
forms, and its interaction with sulphur compounds, particularly
glutathione, and its enzyme systems.


 


Dr Jacobi met Dr Shade at the Bioceuticals Research Symposium in
Sydney, 2017, and was riveted by his presentation on
detoxification.


 


Topics discussed in this episode include:


The liver, gallbladder, and GI connection, and how to align
them so as to clear gastrointestinal issues.

How failure to move bile is at the heart of detox reactions

Bile as a detergent in the small intestine and how bile
can be a core issue in SIBO.



Bile acid destruction and fat malabsorption in SIBO.

Emunctories and what this means.

Drainage areas and how the extracellular space is
cleared.



Metal binder for the GI tract that is far better than
chlorella - IMD microsilica

Toxin conjugates and their interaction with bile salts.

Phosphatidylcholine (PC), its requirement to fluidise the
bile, and choline’s relationship to cholestasis.

Lipopolysaccharide (LPS) endotoxins from leaky gut (from
SIBO) creating inflammation in the hepatocytes and the flow on
effects from this.

Phase 3 detoxification - The role of bile flow in lessening
detoxification reactions through lowering toxic conjugate buildup
in the blood, and instead moving them through the proper
elimination channels.

The importance of addressing emunctories in treating skin
conditions.

How LPS impairs phase 3 in the liver.

Neurological consequences of leaky gut, SIBO, and of a
backfiring liver.

Neuroinflammation, LPS, and a leaky blood brain barrier.

Movement of metals into the urinary flow and how it has
nothing to do with glomerular filtration rate (GFR), even though
this is what is commonly measured for kidney function.

Organic anion transport peptide’s (OATP) role in bringing
toxic conjugates from the blood into the proximal tubular
epithelial cells in the kidneys, then the movement of the
toxic conjugates into the urinary flow through the MRP2
transporter.

MRP2 and how LPS and metals can block it.



How the same things that shut down liver transport of toxic
conjugates, can also shut down kidney transport.

Does LPS affect GFR?

Active transport of toxins happens in the proximal tubules of
the kidney, not in the glomerulus.

Kidney disfunction and how SIBO can be related to proximal
tubule damage in the kidney due to the build up of LPS.

Proximal tubule function test available - Mercury Tri-Test
from Quicksilver Scientific.

Genetic Single Nuclear Polymorphisms (SNPs) and how the
transport protein SNPs are commercially uncharted as yet.

How inflammation blocks detoxification.

Chronic infections turning down detoxification.

Ways to address phase 3 detox.

Address under-functioning gallbladder with PC, for
example.

Address leaky gut so that toxins dumped into small
intestine do not recirculate.

Strong bitters before meals.

Take multi-toxin binder (30 minutes after taking bitters)
- this is important to do 30 minutes after bitters.

Dr Nirala Jacobi uses Toxaprevent, but not in SIBO-C
patients.

Dr Shade uses:

Charcoal

Clay

Chitosan

Metal binder eg. IMD (much stronger than
chlorella), Chlorella.

Acacia gum

For leaky gut

Low FODMAPS

Bifidogenic prebiotic



Powdered Aloe

Marshmallow root

Slippery elm



Is there a test to assess phase 3 detox function?

NRF2 upregulators and their role in cellular
detoxification, to be implemented AFTER liver and kidney
detoxification is streamlined.

The importance of NRF2 and the effects it has on the
body.

Dr Shade’s universal binder - Ultra Binder

How to access Dr Shade’s products.

Dr Shade’s recipe for a self made toxin binder.

The importance of Myrrh in the bitters

The bitter detoxifier in ayurvedic medicine, qi
and blood mover in chinese and ayurvedic medicine,
and strong antimicrobial.

Cautions with long term myrrh supplementation.

Other herbals bitters to include:

Dandelion

Solidago (Golden Rod)

Gentian



Dr Jacobi’s bitters blend

Dandelion

Oregon grape

Gentian

Baical Skullcap



Bitters as opening up the bile, tonifying the
kidneys, and restoring ileocecal valve function.

What is the function of bitter receptors on the
ovaries?

If SIBO clients are Hydrogen Sulfide dominant
note that the bacteria involved here are bile loving,
so any cholagogues will exacerbate the SIBO issue.

Does charcoal absorb all of your minerals?

Using charcoal as the primary binder -
amounts to take and rationale for diversifying
binder portfolio.



Is mercury stored in biofilm?

Is it advised to disrupt biofilm, or is it
dangerous to do so?

EDTA as a biofilm breaker.

Plaques in the vascular system are actually
biofilms.

What mercury testing is offered at Quicksilver
Scientific?

Is it worth testing for mercury toxicity?

When is it good to test people for mercury
toxicity?

How healing the GI tract can heal the kidneys.

What is the evil of amalgam fillings?

Why people with amalgams often have to urinate a
lot at night.

The body has it’s own inbuilt chelating system -
glutathione, glutathione-s-transferase, and the
transport proteins.

What are the myths of chelation agents?

Is lipoic acid a chelator, or is it upregulating
the body’s natural chelation system?

The importance of lining up all the drainage, and
lining up all the phases of detoxification.

Hydrotherapy for the lymphatics.

The issues in Australia with lead and aluminum -
Dr Shade’s recommendation on how to test these areas:

Nutripath’s Blood Metals Assay



Excess copper in the presence of low zinc can
become synergistically toxic with all toxic metals.

Whole blood vs intracellular for testing?

How do you measure intracellular stores?

Residence time in the blood of different metals.

Dr Shade’s last pearls of wisdom - start with
drainage, then move to mobilisation after levels come
down first with good drainage.









 


Resources


Quicksilver Scientific

Dr Shade’s Quicksilver Scientific Youtube channel

Proximal tubule function test available - Mercury Tri-Test
from Quicksilver Scientific.

Tri-test is available through Nutripath



Ultra Binder by Quicksilver Scientific for detoxification

Bitter X by Quicksilver Scientific

Klinghardt therapy