Microbiome Restoration with Dr Jason Hawrelak

In today’s episode, Dr Nirala Jacobi welcomes back Dr Jason
Hawrelak, to talk about Microbiome Restoration.


Dr Hawrelak is a researcher, educator, naturopath, and
nutritionist with over 16 years of clinical experience.  He
also practices at Gould’s Natural Medicine - a 135-year-old
natural medicine apothecary and clinic in Hobart, Tasmania,
Australia.


Dr Hawrelak completed his PhD examining the capacity of
probiotics, prebiotics, and herbal medicines to modify the
gastrointestinal tract microbiota.  He is the senior
lecturer in Complementary and Alternative Medicines at the
University of Tasmania’s School of Medicine where he coordinates
the evidence-based complementary medicines programs.  Dr
Hawrelak also teaches the gastrointestinal imbalances unit,
within the Masters of Science and Human Nutrition, and Functional
Medicine Program at the University of Western States, in
Portland, Oregon.


 


Topics discussed include:


The SIBO Doctor courses

Microbiome Restoration - coming soon



Regrowing vs killing in the microbiome.

Colonic collateral when we are dealing with SIBO, and the
necessity to restore the colonic ecosystem as part of the SIBO
treatment.

How do we learn to interpret the DNA readings and PCR
reports?

The SIBO Doctor Microbiome Restoration course



A discussion of the modules offered in the Microbiome
Restoration course

Module 1 - Testing

The difference between different labs

Culturing vs DNA techniques

Assessment, Interpretation, and Diagnosis



Module 2 - Beneficial Bacteria, including

Akkermansia

Faecalibacterium prausnitzii

Butyrate-producing microbes

Hydrogen sulfide gas producers



Module 3 - Pathobionts

The good, the bad, the ugly

Hydrogen sulfide producers

Methanobrevibacter smithii

coli

Bacteroides



Triple antibiotic therapy (for conditions such as H.
Pylori and Blastocystis Hominis) and the impact on the
colonic ecosystem balance of symbionts and pathobionts.

Dietary changes vs probiotic supplements to elicit change
in the gut microbiome.

The complications between advising prebiotic nutrition
for optimising microbiome restoration, whilst clients are on
therapeutic diets such as the Low FODMAP diet - how to
reconcile?

Hydrogen sulfide breath testing - coming soon.

High-fat content diets in SIBO, and how this can
eventually feed hydrogen sulfide producing bacteria.

Symptoms such as food reactivity and visceral sensitivity
as a consequence of dietary choices in SIBO treatment, in
regards to hydrogen sulfide producing bacterial blooms.

The therapeutic benefits of Soy Isoflavones in relation
to Methane and Hydrogen Sulfide producing SIBO patients.

Equol producers - patients who have bacteria that
convert soy isoflavones into the bioactive component,
Equol.

Adlercreutzia levels in people who eat soy products
as a long-term dietary choice.



Is there a connection between histamine intolerance,
salicylate intolerance, and oxalate intolerance and
microbiome disturbances?

Post SIBO treatment food sensitivities - the colonic
microflora patterns to observe.

Hydrogen sulfide gas and how it causes visceral
sensitivity, gut leakiness, and inflammation in the nerves.

Dietary changes with people with sensitivities - a
reiteration of start low, go slow.

Is there any clinical significance to oxalobacter
formigenes being elevated?

What is the dietary impact of the extinction of
oxalobacter formigenes?

Testing levels of Proteobacteria to uncover the innate
endotoxin load (proteobacteria - gram-negative bacteria that
secrete proinflammatory endotoxins).

The systemic repercussions of endotoxemia - leaky
blood-brain barrier, gut damage, insulin sensitivity impacts,
systemic inflammation, Alzheimer's, anxiety and depression
links.

Endotoxin (also known as Lipopolysaccharides - LPS)
absorption and high-fat

How do different Phyla respond to different diets?

Potential outcomes of the ketogenic diet depending on the
dietary nuances - decreased microflora diversity, increased
hydrogen sulfide gas-producing bacteria, and increased
numbers of proteobacteria.

Akkermansia and constipation - why are these often seen
together?

Gut inflammation and mucus tend to increase Akkermansia
if it is there - it is a mucin eater.

Gut markers of inflammation, such as calprotectin.

The vocabulary to use around probiotics - not re-seeding,
but rather restoring.

The importance of lactic and acetic acid production
adjusting the pH of our microbiome to be hospitable to
beneficial bacteria.

D-Lactate considerations.

Biogaia effectively reducing methane production, and also
being used alongside proton pump inhibitors (PPIs) to prevent
the development of SIBO.

PPIs - when to use and when not to - listen to Dr Steven
Sandberg-Lewis’ podcast on SIBO and Functional GIT Exam
Skills.

Plantarum LP8 is being used in research to decrease
Desulfovibrio, increase butyrate and bifidobacterium - can we
use other strains of L. Plantarum to elicit similar changes?

Plantarum strains to use in gut rehabilitation.

Reuterin production.

Dr Hawrelak’s antimicrobial and dietary recommendations
for treating Desulfovibrio.





 


Resources


Dr Hawrelak


Probiotic Advisor

Gould’s Natural Medicine



 


The SIBO Doctor Microbiome Restoration Course with Dr Jason
Hawrelak [Opens 13 June]


Sign Up for the Course and Live Q & A with Dr Hawrelak



The SIBO Conference New Orleans - speakers mentioned


Dr Richard McCallum

Dr Matthew Bohm



 


Labs mentioned


Ubiome - microbiome DNA testing

Genova



 


Dr Satish Rao


SIBO and comorbid SIFO

D-Lactic Acidosis researcher



 


Dr Steven Sandberg-Lewis


Dr Steven Sandberg-Lewis’ podcast on SIBO and Functional GIT
Exam Skills