#5 Restoring invisible and abandoned trials – Peter Doshi

Clinical trials are the “gold standard” of evidence-based
medicine – the best way we have to test whether a drug is safe
and effective before it enters the market. But if trial data is
poorly reported or – even worse – left unpublished, how are we
supposed to determine the true value of a medical treatment?
Peter Doshi from the RIAT Support Center has made it his mission
to fix the problem and improve data transparency for good.


Tune in to find out:


How publication and reporting biases affect our understanding
of trial results

How an investigation into anti-influenza drugs helped
galvanise a general movement towards greater data
transparency 

How the RIAT Support Center is facilitating the correction of
the scientific record



Want to know more?


The Restoring Invisible & Abandoned Trials (RIAT) Support
Center offers free support to researchers anywhere in the world
that would like to publish an unpublished trial or correct a
misreported trial.

The AllTrials campaign calls for all past and present clinical
trials to be registered and their results reported.

The Tamiflu campaign highlighted important discrepancies between
journal publications and the underlying clinical study reports,
and increased awareness of the importance of independent access
to underlying trial data.

A 2016 systematic review found that much of the information on
adverse events remains unpublished and that the number and range
of adverse events is higher in unpublished than in published
versions of the same study.

Authors from the European Medicines Agency debate whether
clinical trial publications are a sufficient basis for healthcare
decisions.

Peter Doshi and David Healy argue that doctors should not
recommend COVID-19 treatments and vaccines when full data are not
publicly available.






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