BS 211 Molecular Biologist Seth Grant

This episode of Brain Science features the
return of molecular biologist Seth Grant. We briefly review his
decades of research into the complexity of the protein structure
of the synapse and then we focus on his most recent paper, which
describes how the life-span of synapse proteins appears to change
as animals age. Grant reflects of the significance of this
finding both for animal research and human medicine.


Papers discussed in this episode: 



Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker,
D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A.,
Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M.,
O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A.,
Fransén, E., & Grant, S. G. N. (2022). A brain atlas of
synapse protein lifetime across the mouse lifespan. Neuron,
110(24), 4057–4073.e8.
https://doi.org/10.1016/j.neuron.2022.09.009

Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama,
N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide
atlas of synapses across the mouse life span. Science (New
York, N.Y.), 369(6501), 270–275.
https://doi.org/10.1126/science.aba3163



Seth Grant has previously appeared on Brain
Science several times including BSP 51, BSP 101, BS
137, BSP 150 and BS 176.



 


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