Sarina Elmariah, MD, PhD, MPH - Addressing the Burden of Prurigo Nodularis: Expert Insight on Disease Pathogenesis and the Clinical Potential of Novel Therapeutic Options

Go online to PeerView.com/DTN860 to view the activity, download
slides and practice aids, and complete the post-test to earn
credit. Prurigo nodularis (PN) is a chronic inflammatory skin
disease characterized by intensely pruritic, hyperkeratotic nodules
symmetrically distributed on the trunk and extremities. PN is
defined by intense pruritus lasting ≥6 weeks, history of repeated
scratching, and subsequent development of pruritic, elevated, firm,
and nodular skin lesions, in a vicious itch–scratch cycle. The
intense itch associated with PN leads to sleep disturbances and
reduced social participation and work productivity, resulting in a
drastically reduced quality of life and psychosocial disturbances.
Unfortunately, these issues experienced among patients with PN are
further compounded by the lack of effective treatment options. In
this activity, based on a recent live educational symposium, a
panel of experts addresses real-world questions and dilemmas faced
by providers and the PN patients for whom they care. By providing
practical guidance on how to effectively integrate the latest
evidence and expert recommendations into real-world clinical
scenarios, this activity provides participating clinicians with the
necessary tools to effectively navigate the rapidly changing
landscape for PN. Additionally, patient videos are utilized
throughout to convey key information regarding the burden of PN and
optimal management strategies. Upon completion of this activity,
participants should be better able to: Discuss the impact on
quality of life and economic implications of prurigo nodularis
(PN), Describe the pathophysiology of PN as it relates to
clinically relevant disease mechanisms and novel therapeutic
targets, Evaluate emerging treatment options for PN in the context
of mechanism of action, efficacy, and safety, Treat PN in
accordance with current evidence and expert recommendations,
recognizing that an effective treatment approach should be based on
clinical judgment and tailored to the individual needs of the
patient.