Fischöltherapie bei Mukoviszidose

Rationale: Chronic inflammation induces progressive pulmonary
destruction in CF. In previous in vitro studies we found n-3 fatty
acids to effectively suppress the secretion of proinflammatory
5-lipoxygenase products from CF neutrophils (Eur J Clin Invest
1995;25:915-9). Hence, we studied the clinical effects of long-term
fish oil treatment in CF. Method: In a double blind, randomised
multicenter trial, 69 CF patients aged 7-34 years were assigned to
fish oil capsules (F, 36 mg long chain n-3/kg&d; n=35, mean age
13.6 y)or corn oil (P; n=35, 14.8 y) for 12 months and followed for
15 months. Clinical and biochemical data were monitored at 3monthly
visits. Results: Mean plasma phospholipid eicosapentaenoic acid
increased from 0.9% to 2.8% in F (p