Nachweis Kontrastmittel-markierter humaner hämatopoetischer Vorläuferzellen im Mausmodell mit der Magnetresonanztomographie

The objective of this study was to monitor the in vivo distribution
of the iron oxide and gadophrin labeled human hematopoetic
progenitor cells in nude mice using MRI and optical imaging.
Techniques for cell-labelling with MR contrast agents and
subsequent in vivo depiction by imaging modalities were developed
and optimized. Conclusion: The biodistribution of iron oxide as
well as gadophrin labeled progenitor cells can be monitored with
1.5 tesla standard MRI-scanners in vivo. The distribution of the
iron oxide labeled cells to the target organs liver, spleen and
bone marrow was proven histologically. The biodistribution of
gadophrin could be verified by optical imaging. The applied
contrast agents could be useful for clinical applications in the
future.