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  4. #162 - Meet The Scientist Who Says We've Gotten Cancer Completely Wrong
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Carlos Sonnenschein is Professor of Integrative Physiology and
Pathobiology at Tufts University School of Medicine. With Ana
Soto, he developed the tissue organisation field theory of
cancer: the idea that a tumour begins not in a rogue cell, but in
the breakdown of the tissue around it. For fifty years he has
argued that cancer research has been looking one level too low.
Here he explains why the mutations we find in tumours may be the
wreckage, not the cause.

Expect to learn:

- The default state: why every cell's natural tendency is to
proliferate

- Growth factors: why he argued they don't exist, and why people
laughed

- Mutations without cancer: why he says no gene has been shown to
cause a cancer

- Targeted therapy: why he believes the target was never really
there

- Cellular agency: how life, proliferation and motility fit
together

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GS EPISODES MENTIONED

Michael Levin - Michael Levin: Bioelectricity, Morphogenesis,
Platonic Spaces & Xenobots: https://youtu.be/LTBZRVKUwyM

GUEST LINKS

Google Scholar:
https://scholar.google.com/citations?user=VmTCfroAAAAJ

IEA Nantes Fellow Profile:
https://www.iea-nantes.fr/en/fellows/carlos-sonnenschein

Biological Purpose Project:
https://www.biologicalpurpose.org/people/carlos-sonnenschein

ResearchGate:
https://www.researchgate.net/profile/Carlos-Sonnenschein

An Integrative Approach Toward Biology, Organisms, and Cancer
(2018): https://pubmed.ncbi.nlm.nih.gov/29119499

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FOLLOW EVAN

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TIMESTAMPS

0:00:00 Trailer

0:02:26 From Paediatrics to Cancer Research

0:05:23 The Oestrogen Paradox

0:08:43 Proliferation Is the Default State of Every Cell

0:12:27 Inhibitors of Inhibitors

0:14:06 "Growth Factors Don't Exist"

0:15:31 The Somatic Mutation Theory

0:17:41 The Society of Cells and the Tissue Theory of Cancer

0:21:44 Stars and Dogs: Funding a Minority View

0:23:49 Teaching Cancer Through Genetics

0:25:01 How Does Tissue Keep Cells in Check?

0:26:04 Metastasis

0:28:34 Prostate Cancer and Spontaneous Regression

0:30:38 The Cost of Cancer Treatment

0:31:49 Melanoma, UV and the Standard Model

0:32:24 Mutations Without Cancer

0:35:17 No Gene Causes Cancer: BRCA1, p53 and RAS

0:37:00 Why Targeted Therapy Isn't Targeted

0:38:03 When Treatment Causes Cancer

0:40:39 What Does Genome Sequencing Tell You?

0:42:24 Why Does Cancer Run in Families?

0:45:41 Trauma, Healing and Tissue Robustness

0:47:59 A Theory of Organisms

0:50:59 What Is Life?

0:52:18 Economics Is a Branch of Biology

0:53:36 Cellular Agency

0:58:36 Defining Life: Proliferation and Motility

1:01:36 When Did Cells Become Agents?

1:04:49 The Future of Cancer Research

1:09:52 Final Thoughts

.....Email for sponsorship enquiries: evan@thegiantsshoulder.com
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„#162 - Meet The Scientist Who Says We've Gotten Cancer Completely Wrong“

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