Dr. Dominic D’Agostino (@DominicDAgosti2)
is a tenured associate professor in the Department of Molecular
Pharmacology and Physiology at the University of South Florida
Morsani College of Medicine and a Visiting Senior Research
Scientist at the Institute for Human and Machine Cognition.
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*
Timestamps:
[00:00:00] Who is Dominic D'Agostino?
[00:04:37] Ketosis benefits: Quieting the mind, GABA
elevation, metabolic psychiatry.
[00:09:24] My Lyme disease story: Pseudo-dementia reversed in
3-4 days of ketosis.
[00:13:50] Spirochetes are glycolytic: Starve the bug, boost
the immune response.
[00:19:20] Ketosis and cancer: Slowing glycolytic tumors,
enhancing standard care.
[00:20:50] My 18-day keto experiment: Mood stabilization,
Alzheimer’s prevention hopes.
[00:23:19] Metabolic memory: Carryover effects and Valter
Longo’s fasting mimicking research.
[00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m.
eating window.
[00:29:15] Dom’s budget keto meal: Canned mackerel, MCT oil,
apple cider vinegar.
[00:33:28] My ketone measurement paradox: Feeling sharp at
0.2 mM readings.
[00:36:56] The carburetor analogy: Ketone production vs.
utilization explained.
[00:38:43] Breath ketones vs. blood ketones: Better indicator
in caloric deficit.
[00:39:47] Gluconeogenesis fears: Fat, fiber, and salt to
slow protein absorption.
[00:45:25] The bunless double cheeseburger question: 80 grams
of protein in one sitting.
[00:49:03] Post-meal walking and GLUT4 activation: Timing
your glucose disposal.
[00:51:02] CGM and ketone monitor limitations: When your
devices gaslight you.
[00:58:05] Rabbit starvation and protein-veggie days: Why
your body won’t bankroll its own ketosis.
[01:05:44] Alzheimer’s prevention: Biomarkers, B12, hsCRP,
and metabolic health.
[01:09:40] My family history: Letrozole, metabolic
dysfunction, and rapid cognitive decline.
[01:13:17] Minimum effective dose: 80% of benefits from
low-carb Mediterranean.
[01:18:56] One week per month protocol: Aggressive calorie
cut to ramp ketones.
[01:23:12] GKI sweet spot: Target 1-4, aim for 1-2 during
intensive weeks.
[01:36:22] Exogenous ketones 101: Palatability, tolerability,
pharmacokinetics, toxicity.
[01:39:21] 1,3-Butanediol warnings: Liver toxicity, NAD
depletion, dependency risk.
[01:54:22] Intermittent fasting vs. ketogenic breakfast.
[01:59:09] My accidental intoxication story.
[02:03:23] Dr. Veech tribute: Student of Hans Krebs, ketone
ester pioneer.
[02:05:08] Fiber on keto: Wild blueberries, broccoli, apples,
walnuts.
[02:09:58] The tainted gummies incident: Dom’s forensic
investigation underway.
[02:13:08] Thanks to Dr. Boz and Medifoodz.
[02:16:19] Parting thoughts.
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