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  4. #868: Tim’s Founder Kitchen — From Brainstorm to The President’s Office in Two Months (Featuring Jake Becraft, Strand Therapeutics)
Jake Becraft is the CEO and co-founder of Strand
Therapeutics, a company building one of the most
advanced programmable genetic medicine platforms in
biotechnology. Under his leadership, Strand is redefining what
RNA medicines can do by enabling cell-selective targeting and
therapeutic payload delivery inside the body, unlocking a new
class of precision genetic therapies.

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Timestamps:

[00:00:00] Start.

[00:06:07] What Strand does.

[00:08:19] The Boston dinner.

[00:11:05] The image of a body riddled with cancer.

[00:15:05] What stuck for the muggles in the pitch deck.

[00:17:14] A good drug vs. a good product.

[00:19:40] Tricking cancer into snitching on itself.

[00:27:38] The abscopal effect.

[00:34:04] Potency, specificity, and delivery.

[00:35:46] First principles thinking.

[00:36:38] The precipice of a revolution.

[00:41:14] The thousand people in the room.

[00:48:38] Psychedelic medicine as a cautionary tale.

[00:51:17] What actually catches a policymaker’s attention.

[00:53:42] Breakthrough vs. incremental.

[00:54:55] What’s in it for the policymakers?

[00:58:08] The 80/20 wish list.

[01:01:31] Australia’s CTN system.

[01:03:51] Sheep, psychedelics, and red-tape arbitrage.

[01:05:22] China’s clinical-trial flywheel vs. slow-motion
American loss.

[01:06:53] The bicoastal biotech ethos.

[01:08:10] Can the FDA actually pull this off?

[01:12:12] The Sophie’s Choice of pharma development.

[01:14:16] Lost arts of founder mode.

[01:15:23] Rockets for tumors, T-cells, and beyond.

[01:19:16] Viral in policy circles.

[01:23:09] The Washington Post headline and the PickFu split
test.

[01:27:56] Solution-first storytelling.

[01:33:54] RNA medicine and platform therapeutics.

[01:39:17] Moderna’s 62 days.

[01:40:33] Uber Eats and the de-risked launch.

[01:44:17] CEO blockers.

[01:45:52] Where’s biotech’s SpaceX moment?

[01:46:53] Elon Musk betting black on the wheel.

[01:51:55] AWS and the post-conviction / pre-consensus
window.

[01:58:47] COVID politicization.

[01:59:46] Insulin, growth hormone, and the original platform
story.

[02:01:35] Biotech as pharma’s little brother.

[02:03:29] More recent role models, Apple edition.

[02:04:50] Art Levinson, Steve Jobs, and the biotech-tech
crossover.

[02:06:25] The iPhone as a delivery platform.

[02:08:25] Spotify’s problem and the future of bespoke
medicine.

[02:10:07] Baby KJ and the limits of liver-only solutions.

[02:11:19] Parting thoughts.

*

For show notes and past guests on The
Tim Ferriss Show, please visit
tim.blog/podcast.

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